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Estrobin, also known as α,α-di(p-ethoxyphenyl)-β-phenylbromoethylene and commonly abbreviated as DBE, is a synthetic, nonsteroidalestrogen of the triphenylethylene group that was never marketed.[1][2]Chlorotrianisene, and subsequently clomifene and tamoxifen, were derived from it.[1][2] Estrobin, similarly to other triphenylethylenes, is very lipophilic and hence very long-lasting in its duration of action.[1][2] Similarly to chlorotrianisene, estrobin behaves a prodrug to a much more potent estrogen in the body.[2]
^ abcdWelsh AL (April 1954). "Use of synthetic estrogenic substance chlorotrianisene (TACE) in treatment of acne". A.M.A. Archives of Dermatology and Syphilology. 69 (4): 418–27. doi:10.1001/archderm.1954.01540160020004. PMID13147544.
