Estropipate

From Wikipedia, the free encyclopedia
Jump to: navigation, search
"Ogen" redirects here. For the character in the Japanese anime, see Ogen (Basilisk).
Estropipate
Estropipate.png
Clinical data
AHFS/Drugs.com Monograph
ATC code
  • none
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.027.906
Chemical and physical data
Formula C22H32N2O5S
Molar mass 436.56 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Estropipate (INN, USAN, BAN) (brand names Harmogen, Improvera, Ogen, Ortho-Est, many others), also known as piperazine estrone sulfate, is a semi-synthetic, steroidal estrogen that is used mainly in hormone replacement therapy in the treatment of symptoms of menopause.[1][2] It is a salt of estrone sulfate and piperazine, and is hydrolyzed into estrone in the body.[1][2]

Uses[edit]

Estropipate is used to:

Pharmacology[edit]

Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of SLCO1B1 (OATP1B1) (IC50 = 70 nM).[1]

See also[edit]

References[edit]

  1. ^ a b J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 900–. ISBN 978-1-4757-2085-3. 
  2. ^ a b I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 114–. ISBN 978-94-011-4439-1.