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Clonitazene

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Clonitazene
Clinical data
Other namesClonitazene
ATC code
  • none
Legal status
Legal status
Identifiers
  • 2-[2-[(4-chlorophenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H23ClN4O2
Molar mass386.88 g/mol g·mol−1
3D model (JSmol)
  • [O-] [N+](=O)c3ccc1c(nc(n1CCN(CC)CC)Cc2ccc(Cl)cc2)c3
  • InChI=1S/C20H23ClN4O2/c1-3-23(4-2)11-12-24-19-10-9-17(25(26)27)14-18(19)22-20(24)13-15-5-7-16(21)8-6-15/h5-10,14H,3-4,11-13H2,1-2H3 checkY
  • Key:GPZLDQAEBHTMPG-UHFFFAOYSA-N checkY
  (verify)

Clonitazene is an opioid analgesic of approximately three times the potency of morphine.[citation needed] It is related to etonitazene, an opioid of significantly higher potency. Clonitazene is not currently marketed. It is a controlled substance; in the United States it is a Schedule I Narcotic controlled substance with a DEA ACSCN of 9612 and an annual manufacturing quota of zero.

Synthesis

Clonitrazine synthesis:[1] Hoffmann et al., U.S. patent 2,935,514 (1960 to Ciba).

References

  1. ^ Hunger, A.; Kebrle, J.; Rossi, A.; Hoffmann, K. (1957). "Synthese basisch substituierter, analgetisch wirksamer Benzimidazol-Derivate". Experientia. 13 (10): 400–1. doi:10.1007/BF02161116. PMID 13473817.