DUSP10

DUSP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZZW, 2OUC, 2OUD, 3TG1
Identifiers
Aliases	DUSP10, MKP-5, MKP5, dual specificity phosphatase 10
External IDs	OMIM: 608867; MGI: 1927070; HomoloGene: 5215; GeneCards: DUSP10; OMA:DUSP10 - orthologs
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	183,807,833 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; stromal cell of endometrium; ; right lobe of liver; ; triceps brachii muscle; ; vastus lateralis muscle; ; retinal pigment epithelium; ; body of pancreas; ; deltoid muscle; ; monocyte; ; amniotic fluid;
	Top expressed in
	temporal muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; zygote; ; medial head of gastrocnemius muscle; ; skeletal muscle tissue; ; thymus; ; masseter muscle; ; digastric muscle; ; soleus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; JUN kinase binding; MAP kinase phosphatase activity; mitogen-activated protein kinase p38 binding; phosphoprotein phosphatase activity; protein tyrosine/threonine phosphatase activity; protein binding;
Cellular component	Golgi apparatus; nucleoplasm; cytosol; nuclear speck; nucleus; cytoplasm;
Biological process	regulation of innate immune response; regulation of adaptive immune response; oligodendrocyte differentiation; negative regulation of respiratory burst involved in inflammatory response; response to organic substance; response to lipopolysaccharide; negative regulation of oligodendrocyte differentiation; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of stress-activated MAPK cascade; regulation of brown fat cell differentiation; dephosphorylation; positive regulation of regulatory T cell differentiation; protein dephosphorylation; negative regulation of epithelial cell migration; negative regulation of cell migration; peptidyl-threonine dephosphorylation; negative regulation of JUN kinase activity; negative regulation of JNK cascade; negative regulation of epithelial cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of p38MAPK cascade; negative regulation of epithelium regeneration; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	11221
	63953
	n/a
	ENSMUSG00000039384
	Q9Y6W6
	Q9ESS0
	NM_007207; NM_144728; NM_144729
	NM_022019
	NP_009138
	NP_071302
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.^[4]^[5]^[6]

Template:PBB Summary

Interactions

DUSP10 has been shown to interact with MAPK14^[7]^[8]^[9] and MAPK8.^[4]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039384 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Tanoue T, Moriguchi T, Nishida E (Aug 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. PMID 10391943.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A (Jan 2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene. 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297.
^ "Entrez Gene: DUSP10 dual specificity phosphatase 10".
^ Tanoue, T; Moriguchi T; Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. 274 (28). UNITED STATES: 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Tanoue, T; Yamamoto T; Maeda R; Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. 276 (28). United States: 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Tanoue, T; Maeda R; Adachi M; Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. 20 (3). England: 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Interactions

References

Further reading