Encainide
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Clinical data | |
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Trade names | Enkaid |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a605040 |
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Chemical and physical data | |
Formula | C22H28N2O2 |
Molar mass | 352.47 g/mol g·mol−1 |
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Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.[1]
Synthesis
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See also
References
- ^ Echt, D. S.; Liebson, P. R.; Mitchell, L. B.; Peters, R. W.; Obias-Manno, D.; Barker, A. H.; Arensberg, D.; Baker, A.; Friedman, L.; Greene, H. L.; Huther, M. L.; Richardson, D. W. (1991). "Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo". New England Journal of Medicine. 324 (12): 781–788. doi:10.1056/NEJM199103213241201. PMID 1900101.
- ^ S.J. Dykstra, J.L. Minelli, DE 2210154 (1972).
- ^ S.J. Dykstra, J.L. Minelli, U.S. patent 3,931,195 (1976).
- ^ Dykstra, Stanley J. (1973). "Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines". Journal of Medicinal Chemistry. 16 (9): 1015–1020. doi:10.1021/jm00267a012. PMID 4745503.