Ephrin-B3 is a protein that in humans is encoded by the EFNB3gene.[5][6]
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EphrinB3 has been implicated in mediating various developmental events, particularly in the nervous system. EphrinB3 reverse signaling is important for axon pruning and synapse and spine formation during postnatal development of the nervous system.[7][8] Previous work has also shown that signaling through this ligand is important for radial migration during cortical development.[7] Moreover, levels of EFNB3 expression are particularly high in several forebrain subregions compared to other brain subregions, and may play a pivotal role in forebrain function. It has been suggested that ephrinB3 signaling is necessary for synaptic plasticity to occur in the hippocampus; this implicates ephrinB3 as a major player in learning and memory.[8] More recently, ephrinB3 has been shown to regulate proliferation of neural stem cells in the adult subventricular zone (SVZ).[7][9]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tang XX, Pleasure DE, Ikegaki N (May 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics. 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID9126477.
^ abcRodger, Jennifer; Lorena Salvatore; Paolo Migani (2012). "Should I Stay or Should I Go? Ephs and Ephrins in Neuronal Migration". Neurosignals. 20 (3): 190–201. doi:10.1159/000333784. PMID22456188.
^ abHruska, Martin; Matthew B. Dalva (2012). "Ephrin regulation of synapse formation, function and plasticity". Molecular and Cellular Neuroscience. 50 (1): 35–44. doi:10.1016/j.mcn.2012.03.004. PMID22449939.
^Ricard, Jerome; Jessica Salinas; Lissette Garcia; Daniel J. Liebl (2006). "EphrinB3 regulates cell proliferation and survival in adult neurogenesis". Molecular and Cellular Neuroscience. 31 (4): 713–22. doi:10.1016/j.mcn.2006.01.002. PMID16483793.