PTPN2

PTPN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1L8K
Identifiers
Aliases	PTPN2, PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP, protein tyrosine phosphatase, non-receptor type 2, protein tyrosine phosphatase non-receptor type 2
External IDs	OMIM: 176887; MGI: 97806; HomoloGene: 7497; GeneCards: PTPN2; OMA:PTPN2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	12,929,643 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	67,857,665 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; monocyte; ; granulocyte; ; tonsil; ; cartilage tissue; ; parotid gland; ; oocyte; ; lymph node; ; body of pancreas; ; gonad;
	Top expressed in
	otic placode; ; saccule; ; condyle; ; primary oocyte; ; fossa; ; Paneth cell; ; hair follicle; ; secondary oocyte; ; submandibular gland; ; primitive streak;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; phosphatase activity; integrin binding; phosphoprotein phosphatase activity; syntaxin binding; non-membrane spanning protein tyrosine phosphatase activity; receptor tyrosine kinase binding; hydrolase activity; protein tyrosine phosphatase activity; STAT family protein binding;
Cellular component	cytoplasm; membrane; plasma membrane; endoplasmic reticulum; nucleus; endoplasmic reticulum-Golgi intermediate compartment; nucleoplasm; cytosol;
Biological process	negative regulation of type I interferon-mediated signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of PERK-mediated unfolded protein response; dephosphorylation; negative regulation of interleukin-4-mediated signaling pathway; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of interleukin-6-mediated signaling pathway; negative regulation of cell population proliferation; protein dephosphorylation; negative regulation of interleukin-2-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; negative regulation of protein tyrosine kinase activity; regulation of hepatocyte growth factor receptor signaling pathway; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; insulin receptor signaling pathway; negative regulation of interferon-gamma-mediated signaling pathway; glucose homeostasis; negative regulation of chemotaxis; negative regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of macrophage differentiation; negative regulation of T cell receptor signaling pathway; negative regulation of positive thymic T cell selection; negative regulation of insulin receptor signaling pathway; T cell differentiation; negative regulation of ERK1 and ERK2 cascade; erythrocyte differentiation; negative regulation of lipid storage; B cell differentiation; peptidyl-tyrosine dephosphorylation; positive regulation of gluconeogenesis; negative regulation of macrophage colony-stimulating factor signaling pathway; negative regulation of inflammatory response; negative regulation of transcription by RNA polymerase II; negative regulation of tyrosine phosphorylation of STAT protein; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5771
	19255
	ENSG00000175354
	ENSMUSG00000024539
	P17706
	Q06180
	NM_001207013; NM_001308287; NM_002828; NM_080422; NM_080423
	NM_001127177; NM_008977
	NP_001193942; NP_001295216; NP_002819; NP_536347; NP_536348
	NP_001120649; NP_033003
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175354 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024539 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990). "Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B". Proc Natl Acad Sci U S A. 87 (13): 5148–52. doi:10.1073/pnas.87.13.5148. PMC 54279. PMID 2164224.
^ "Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2".

References

Further reading