PTPN9
PTPN9 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | PTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9, protein tyrosine phosphatase non-receptor type 9 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600768; MGI: 1928376; HomoloGene: 2121; GeneCards: PTPN9; OMA:PTPN9 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.[5][6]
Function
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000169410 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032290 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Gu M, Warshawsky I, Majerus PW (May 1992). "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p". Proc Natl Acad Sci U S A. 89 (7): 2980–4. doi:10.1073/pnas.89.7.2980. PMC 48787. PMID 1557404.
- ^ a b "Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9".
Further reading