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PTPN9

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PTPN9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9, protein tyrosine phosphatase non-receptor type 9
External IDsOMIM: 600768; MGI: 1928376; HomoloGene: 2121; GeneCards: PTPN9; OMA:PTPN9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002833

NM_019651

RefSeq (protein)

NP_002824

NP_062625

Location (UCSC)Chr 15: 75.46 – 75.58 MbChr 9: 56.9 – 56.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.[5][6]

Function

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169410Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032290Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gu M, Warshawsky I, Majerus PW (May 1992). "Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p". Proc Natl Acad Sci U S A. 89 (7): 2980–4. Bibcode:1992PNAS...89.2980G. doi:10.1073/pnas.89.7.2980. PMC 48787. PMID 1557404.
  6. ^ a b "Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9".

Further reading

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  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)