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Chemical compound
Pharmaceutical compound
ICI-85966 Other names Stilbostat; Diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate)
[4-[(E )-4-[4-[Bis(2-chloroethyl)carbamoyloxy]phenyl]hex-3-en-3-yl]phenyl] N ,N -bis(2-chloroethyl)carbamate
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) Formula C 28 H 34 Cl 4 N 2 O 4 Molar mass 604.39 g·mol−1 3D model (JSmol )
CC/C(=C(/CC)\C1=CC=C(C=C1)OC(=O)N(CCCl)CCCl)/C2=CC=C(C=C2)OC(=O)N(CCCl)CCCl
InChI=1S/C28H34Cl4N2O4/c1-3-25(21-5-9-23(10-6-21)37-27(35)33(17-13-29)18-14-30)26(4-2)22-7-11-24(12-8-22)38-28(36)34(19-15-31)20-16-32/h5-12H,3-4,13-20H2,1-2H3/b26-25+
Key:BOIZOYRDXIYMCY-OCEACIFDSA-N
ICI-85966 (former tentative brand name Stilbostat ), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate) , is a synthetic , nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard ester of diethylstilbestrol (DES) which was developed for the treatment of breast cancer and prostate cancer but was never marketed (possibly due to the toxicity of DES).[ 1] [ 2] [ 3] [ 4] [ 5]
See also
References
^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. p. 397. ISBN 978-1-4757-2085-3 .
^ Zimel H, Broder D, Zimel A (1973). "[Therapeutic effects of the preparation "Stilbostat" in advanced stages of breast cancer after the menopause]". Stud Cercet Endocrinol (in Romanian). 24 (3): 211–9. PMID 4703920 .
^ Görlich M, Heise E (1976). "Contribution to the mechanism of Stilbostat action". Neoplasma . 23 (4): 363–9. PMID 1004653 .
^ Zimel H, Mogos I, Maltezeanu G (1977). "Estimation of StilbostatR treatment efficiency in breast cancer by thermography". Neoplasma . 24 (5): 553–7. PMID 927612 .
^ Zimel H, Bocancea D (1974). "Treatment of prostatic carcinoma with Stilbostat". Neoplasma . 21 (1): 101–8. PMID 4596007 .
ER Tooltip Estrogen receptor
Agonists
Steroidal: 2-Hydroxyestradiol
2-Hydroxyestrone
3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
3α-Androstanediol
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3β-Hydroxytibolone
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7α-Hydroxy-DHEA
7α-Methylestradiol
7β-Hydroxyepiandrosterone
8,9-Dehydroestradiol
8,9-Dehydroestrone
8β-VE2
10β,17β-Dihydroxyestra-1,4-dien-3-one (DHED)
11β-Chloromethylestradiol
11β-Methoxyestradiol
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16-Ketoestradiol
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17α-Ethynyl-3α-androstanediol
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Lavender oil
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Phytosteroids (e.g., digitoxin (digitalis ), diosgenin , guggulsterone )
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Resorcylic acid lactones (e.g., zearalanone , α-zearalenol , β-zearalenol , zearalenone , zeranol (α-zearalanol) , taleranol (teranol, β-zearalanol) )
Steroid -like (e.g., deoxymiroestrol , miroestrol )
Stilbenoids (e.g., resveratrol , rhaponticin )
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Mixed (SERMs Tooltip Selective estrogen receptor modulators ) Antagonists
Coregulator-binding modulators: ERX-11
GPER Tooltip G protein-coupled estrogen receptor
Agonists Antagonists Unknown