PTPRN

PTPRN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I1Y, 2QT7, 3N01, 3N4W, 3NG8, 3NP5
Identifiers
Aliases	PTPRN, IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, protein tyrosine phosphatase, receptor type N, protein tyrosine phosphatase receptor type N
External IDs	OMIM: 601773; MGI: 102765; HomoloGene: 48142; GeneCards: PTPRN; OMA:PTPRN - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q35 Start 219,289,623 bp End 219,309,648 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C4|1 38.64 cM Start 75,223,671 bp End 75,241,146 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans Brodmann area 10 right frontal lobe right hemisphere of cerebellum pituitary gland anterior cingulate cortex anterior pituitary frontal pole nucleus accumbens Brodmann area 9 Top expressed in superior frontal gyrus primary visual cortex entorhinal cortex perirhinal cortex dentate gyrus of hippocampal formation granule cell CA3 field dorsomedial hypothalamic nucleus nucleus of stria terminalis central gray substance of midbrain supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function spectrin binding protein binding protein tyrosine phosphatase activity transcription factor binding ubiquitin-like protein ligase binding GTPase binding phosphatase activity hydrolase activity Cellular component axon terminus integral component of membrane perikaryon endosome Golgi apparatus cell projection membrane synaptic vesicle plasma membrane transport vesicle membrane synapse secretory granule axon cell junction neuronal cell body cytoplasmic vesicle nucleus Biological process luteinization cytokine-mediated signaling pathway response to reactive oxygen species insulin secretion response to glucose response to estrogen response to insulin response to cAMP dense core granule maturation insulin secretion involved in cellular response to glucose stimulus transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of type B pancreatic cell proliferation peptidyl-tyrosine dephosphorylation protein dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5798 19275 Ensembl ENSG00000054356 ENSMUSG00000026204 UniProt Q16849 Q60673 RefSeq (mRNA) NM_001199763 NM_001199764 NM_002846 NM_008985 NM_001359281 RefSeq (protein) NP_001186692 NP_001186693 NP_002837 n/a Location (UCSC) Chr 2: 219.29 – 219.31 Mb Chr 1: 75.22 – 75.24 Mb PubMed search
Wikidata
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Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

Interactions

PTPRN has been shown to interact with SPTBN4.

Further reading

• Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PM (1994). "Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases". J. Immunol. 152 (6): 3183–8. PMID 8144912.
• Solimena M, Dirkx R, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU (1996). "ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules". EMBO J. 15 (9): 2102–14. doi:10.1002/j.1460-2075.1996.tb00564.x. PMC 450132. PMID 8641276.
• van den Maagdenberg AM, Olde Weghuis D, Rijss J, van de Wetering RA, Wieringa B, Geurts van Kessel A, Hendriks WJ (1996). "Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker". Cytogenet. Cell Genet. 73 (1–2): 145–8. doi:10.1159/000134327. PMID 8646884.
• Cui L, Yu WP, DeAizpurua HJ, Schmidli RS, Pallen CJ (1996). "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes". J. Biol. Chem. 271 (40): 24817–23. doi:10.1074/jbc.271.40.24817. PMID 8798755.
• Xie J, Zhang B, Lan MS, Notkins AL (1999). "Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN)". Genomics. 54 (2): 338–43. doi:10.1006/geno.1998.5583. PMID 9828138.
• Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M (2001). "The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells". Eur. J. Cell Biol. 79 (9): 621–30. doi:10.1078/0171-9335-00095. PMID 11043403.
• Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M, Mizuta M, Eisenbarth GS, Hutton JC (2001). "Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes". Diabetologia. 43 (10): 1293–301. doi:10.1007/s001250051525. PMID 11079748.
• Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M (2001). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001.
• Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C, Hutton J, Eisenbarth GS, Pugliese A (2001). "Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen". Diabetes. 50 (4): 895–900. doi:10.2337/diabetes.50.4.895. PMID 11289059.
• Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M (2001). "Dephosphorylation of β2-syntrophin and Ca2+/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion". EMBO J. 20 (15): 4013–23. doi:10.1093/emboj/20.15.4013. PMC 149140. PMID 11483505.
• Mikulecký M, Michalková D (2002). "Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children". Biomed. Pharmacother. 55 Suppl 1: 106s–109s. PMID 11774856.
• Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U, Eisenbarth GS, Dotta F (2002). "ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies". J. Autoimmun. 18 (2): 191–6. doi:10.1006/jaut.2001.0577. PMID 11908951.
• Kawasaki E, Yamaguchi H, Hattori H, Egashira T, Eguchi K (2002). "Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay". Ann. N. Y. Acad. Sci. 958: 241–6. doi:10.1111/j.1749-6632.2002.tb02978.x. PMID 12021115.
• Sanjeevi CB, Das AK, Shtauvere-Brameus A (2002). "BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India". Ann. N. Y. Acad. Sci. 958: 293–6. doi:10.1111/j.1749-6632.2002.tb02990.x. PMID 12021127.
• Bearzatto M, Lampasona V, Belloni C, Bonifacio E (2004). "Fine mapping of diabetes-associated IA-2 specific autoantibodies". J. Autoimmun. 21 (4): 377–82. doi:10.1016/j.jaut.2003.08.002. PMID 14624760.
• Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M (2005). "Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells". J. Cell Biol. 167 (6): 1063–74. doi:10.1083/jcb.200408172. PMC 2172607. PMID 15596545.
• Ota T, Takamura T, Nagai Y, Bando Y, Usuda R (2005). "Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody". Diabetes Res. Clin. Pract. 67 (1): 63–9. doi:10.1016/j.diabres.2004.05.004. PMID 15620435.