SSH2

SSH2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NT2
Identifiers
Aliases	SSH2, SSH-2, SSH-2L, slingshot protein phosphatase 2
External IDs	OMIM: 606779; MGI: 2679255; HomoloGene: 14116; GeneCards: SSH2; OMA:SSH2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 29,625,938 bp End 29,930,276 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 77,107,113 bp End 77,351,046 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle cardiac muscle tissue of right atrium blood Skeletal muscle tissue of rectus abdominis gastrocnemius muscle quadriceps femoris muscle Skeletal muscle tissue of biceps brachii vastus lateralis muscle white blood cell Top expressed in spermatocyte extraocular muscle digastric muscle temporal muscle sternocleidomastoid muscle interventricular septum soleus muscle vastus lateralis muscle triceps brachii muscle lymph node More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphatase activity actin binding phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm cytoskeleton extracellular space Biological process regulation of lamellipodium assembly regulation of axonogenesis regulation of actin polymerization or depolymerization protein dephosphorylation peptidyl-tyrosine dephosphorylation actin cytoskeleton organization dephosphorylation cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85464 237860 Ensembl ENSG00000141298 ENSMUSG00000037926 UniProt Q76I76 Q5SW75 RefSeq (mRNA) NM_001282129 NM_001282130 NM_001282131 NM_033389 NM_001291190 NM_177710 RefSeq (protein) NP_001269058 NP_001269059 NP_001269060 NP_203747 NP_001278119 NP_808378 Location (UCSC) Chr 17: 29.63 – 29.93 Mb Chr 11: 77.11 – 77.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

For the SSH-2 protocol, see Secure Shell#Version 2.x

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chan SY, Chan AK, Cheung BP, et al. (2004). "Identification of genes expressed during myocardial development". Chin. Med. J. 116 (9): 1329–32. PMID 14527359.
• Ohta Y, Kousaka K, Nagata-Ohashi K, et al. (2004). "Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin". Genes Cells. 8 (10): 811–24. doi:10.1046/j.1365-2443.2003.00678.x. PMID 14531860.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Soosairajah J, Maiti S, Wiggan O, et al. (2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): 473–86. doi:10.1038/sj.emboj.7600543. PMC 548651. PMID 15660133.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kligys K, Claiborne JN, DeBiase PJ, et al. (2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes". J. Biol. Chem. 282 (44): 32520–8. doi:10.1074/jbc.M707041200. PMC 2754063. PMID 17848544.{{cite journal}}: CS1 maint: unflagged free DOI (link)

External links

• Overview of all the structural information available in the PDB for UniProt: Q76I76 (Protein phosphatase Slingshot homolog 2) at the PDBe-KB.