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DnaJ (Hsp40) homolog, subfamily C, member 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DNAJC3 ; ERdj6; HP58; P58; P58IPK; PRKRI
External IDs OMIM601184 MGI107373 HomoloGene2486 GeneCards: DNAJC3 Gene
Species Human Mouse
Entrez 5611 100037258
Ensembl ENSG00000102580 ENSMUSG00000022136
UniProt Q13217 Q91YW3
RefSeq (mRNA) NM_006260 NM_008929
RefSeq (protein) NP_006251 NP_032955
Location (UCSC) Chr 13:
96.33 – 96.45 Mb
Chr 14:
118.94 – 118.98 Mb
PubMed search [1] [2]

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.[1][2][3]


The protein encoded by this gene contains multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).[3]


DNAJC3 has been shown to interact with:


  1. ^ Lee TG, Tang N, Thompson S, Miller J, Katze MG (Apr 1994). "The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins". Mol Cell Biol 14 (4): 2331–42. doi:10.1128/mcb.14.4.2331. PMC 358600. PMID 7511204. 
  2. ^ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (Mar 1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806. 
  3. ^ a b "Entrez Gene: DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3". 
  4. ^ Polyak SJ, Tang N, Wambach M, Barber GN, Katze MG (Jan 1996). "The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity". J. Biol. Chem. 271 (3): 1702–7. doi:10.1074/jbc.271.3.1702. PMID 8576172. 
  5. ^ a b Gale M, Blakely CM, Hopkins DA, Melville MW, Wambach M, Romano PR, Katze MG (Feb 1998). "Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK". Mol. Cell. Biol. 18 (2): 859–71. PMC 108797. PMID 9447982. 
  6. ^ Yan W, Frank CL, Korth MJ, Sopher BL, Novoa I, Ron D, Katze MG (Dec 2002). "Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 15920–5. doi:10.1073/pnas.252341799. PMC 138540. PMID 12446838. 

Further reading[edit]