UBE2H

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UBE2H
Protein UBE2H PDB 1yh6.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDsMGI: 104632 HomoloGene: 103894 GeneCards: UBE2H
EC number2.3.2.24
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for UBE2H
Genomic location for UBE2H
Band7q32.2Start129,830,732 bp[1]
End129,952,949 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202498
NM_003344
NM_182697

NM_001169576
NM_001169577
NM_009459

RefSeq (protein)

NP_001189427
NP_003335
NP_874356
NP_003335.1

NP_001163047
NP_001163048
NP_033485

Location (UCSC)Chr 7: 129.83 – 129.95 MbChr 6: 30.21 – 30.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[5][6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186591 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039159 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. PMID 8132613.
  6. ^ a b "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".

Further reading[edit]