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Ubiquitin-conjugating enzyme E2H
Protein UBE2H PDB 1yh6.png
PDB rendering based on 1yh6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2H ; E2-20K; GID3; UBC8; UBCH; UBCH2
External IDs OMIM601082 MGI104632 HomoloGene103894 GeneCards: UBE2H Gene
EC number
Species Human Mouse
Entrez 7328 22214
Ensembl ENSG00000186591 ENSMUSG00000039159
UniProt P62256 P62257
RefSeq (mRNA) NM_001202498 NM_001169576
RefSeq (protein) NP_001189427 NP_001163047
Location (UCSC) Chr 7:
129.83 – 129.95 Mb
Chr 6:
30.21 – 30.3 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]


  1. ^ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem 269 (12): 8797–802. PMID 8132613. 
  2. ^ a b "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)". 

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