UBE2H

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UBE2H
Protein UBE2H PDB 1yh6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDs MGI: 104632 HomoloGene: 103894 GeneCards: 7328
EC number 2.3.2.24
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202498
NM_003344
NM_182697

NM_001169576
NM_001169577
NM_009459

RefSeq (protein)

NP_001189427.1
NP_003335.1
NP_874356.1
NP_003335.1

NP_033485.1

Location (UCSC) Chr 7: 129.83 – 129.95 Mb Chr 6: 30.21 – 30.3 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[3][4]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. PMID 8132613. 
  4. ^ a b "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)". 

Further reading[edit]