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Ubiquitin-conjugating enzyme E2D 2
Protein UBE2D2 PDB 1ur6.png
PDB rendering based on 1ur6.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2D2 ; E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
External IDs OMIM602962 MGI1930715 HomoloGene2506 GeneCards: UBE2D2 Gene
EC number
RNA expression pattern
PBB GE UBE2D2 201343 at tn.png
PBB GE UBE2D2 201344 at tn.png
PBB GE UBE2D2 201345 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7322 56550
Ensembl ENSG00000131508 ENSMUSG00000091896
UniProt P62837 P62838
RefSeq (mRNA) NM_003339 NM_019912
RefSeq (protein) NP_003330 NP_064296
Location (UCSC) Chr 5:
139.53 – 139.63 Mb
Chr 18:
35.77 – 35.81 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.[1][2]


The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]


UBE2D2 has been shown to interact with:


  1. ^ Jensen JP, Bates PW, Yang M, Vierstra RD, Weissman AM (Dec 1995). "Identification of a family of closely related human ubiquitin conjugating enzymes". The Journal of Biological Chemistry 270 (51): 30408–14. doi:10.1074/jbc.270.51.30408. PMID 8530467. 
  2. ^ a b "Entrez Gene: UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)". 
  3. ^ Mace PD, Linke K, Feltham R, Schumacher FR, Smith CA, Vaux DL, Silke J, Day CL (Nov 2008). "Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment". The Journal of Biological Chemistry 283 (46): 31633–40. doi:10.1074/jbc.M804753200. PMID 18784070. 
  4. ^ a b Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes to Cells 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509. 
  5. ^ a b Hatakeyama S, Jensen JP, Weissman AM (Jun 1997). "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases". The Journal of Biological Chemistry 272 (24): 15085–92. doi:10.1074/jbc.272.24.15085. PMID 9182527. 
  6. ^ a b Yu P, Chen Y, Tagle DA, Cai T (Jun 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302. 

Further reading[edit]