DNAJB6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
DNAJB6
Identifiers
Aliases DNAJB6, Dnajb6, Mrj, mDj4, DJ4, DnaJ, HHDJ1, HSJ-2, HSJ2, LGMD1D, LGMD1E, MSJ-1, DnaJ heat shock protein family (Hsp40) member B6
External IDs MGI: 1344381 HomoloGene: 38058 GeneCards: DNAJB6
RNA expression pattern
PBB GE DNAJB6 208811 s at tn.png

PBB GE DNAJB6 209015 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005494
NM_058246

NM_001037940
NM_001037941
NM_001127367
NM_011847

RefSeq (protein)

NP_005485
NP_490647

Location (UCSC) Chr 7: 157.34 – 157.42 Mb Chr 5: 29.74 – 29.82 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.[3][4][5]

Function[edit]

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[5]

Interactions[edit]

DNAJB6 has been shown to interact with Keratin 18.[6] It has been also shown that the aggregation of Aβ42 (a process involved in e.g. Alzheimer's disease) is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Miyajima N, Saito T (June 1999). "Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family". J Hum Genet. 44 (3): 185–9. doi:10.1007/s100380050139. PMID 10319584. 
  4. ^ Pei L (March 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J Biol Chem. 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854. 
  5. ^ a b "Entrez Gene: DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6". 
  6. ^ Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M (2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. PMID 10954706. 
  7. ^ Månsson, C; Arosio, P; Hussein, R; Kampinga, H H; Hashem, R M; Boelens, W C; Emanuelsson, C (2014). "Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation.". J. Biol. Chem. 289 (45): 31066–76. doi:10.1074/jbc.M114.595124. PMC 4223311Freely accessible. PMID 25217638. 

Further reading[edit]

External links[edit]