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DnaJ (Hsp40) homolog, subfamily B, member 6
Symbols DNAJB6 ; DJ4; DnaJ; HHDJ1; HSJ-2; HSJ2; LGMD1D; LGMD1E; MRJ; MSJ-1
External IDs OMIM611332 MGI1344381 HomoloGene38058 GeneCards: DNAJB6 Gene
RNA expression pattern
PBB GE DNAJB6 208811 s at tn.png
PBB GE DNAJB6 209015 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10049 23950
Ensembl ENSG00000105993 ENSMUSG00000029131
UniProt O75190 O54946
RefSeq (mRNA) NM_005494 NM_001037940
RefSeq (protein) NP_005485 NP_001033029
Location (UCSC) Chr 7:
157.34 – 157.42 Mb
Chr 5:
29.74 – 29.82 Mb
PubMed search [1] [2]

DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.[1][2][3]


This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[3]


DNAJB6 has been shown to interact with Keratin 18.[4]


  1. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Miyajima N, Saito T (June 1999). "Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family". J Hum Genet 44 (3): 185–9. doi:10.1007/s100380050139. PMID 10319584. 
  2. ^ Pei L (March 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J Biol Chem 274 (5): 3151–8. doi:10.1074/jbc.274.5.3151. PMID 9915854. 
  3. ^ a b "Entrez Gene: DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6". 
  4. ^ Izawa I, Nishizawa M, Ohtakara K, Ohtsuka K, Inada H, Inagaki M (2000). "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein". J. Biol. Chem. 275 (44): 34521–7. doi:10.1074/jbc.M003492200. PMID 10954706. 

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