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Protein UBE2B PDB 1jas.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
External IDs MGI: 102944 HomoloGene: 101298 GeneCards: UBE2B
RNA expression pattern
PBB GE UBE2B 202335 s at fs.png

PBB GE UBE2B 202333 s at fs.png

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More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 134.37 – 134.39 Mb Chr 11: 51.99 – 52 Mb
PubMed search [1] [2]
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Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.[3][4]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.[4]


UBE2B has been shown to interact with RAD18.[5][6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696. 
  4. ^ a b "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)". 
  5. ^ Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657Freely accessible. PMID 10908344. 
  6. ^ Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647Freely accessible. PMID 10884424. 

Further reading[edit]