Etoxeridine

Etoxeridine
Clinical data
Other names	Etoxeridine, Carbetidine, Atenos
ATC code	none;
Legal status
Legal status	AU: S9 (Prohibited substance); CA: Schedule I; DE: Anlage I (Authorized scientific use only); UK: Class A; US: Schedule I;
Identifiers
	IUPAC name ethyl 1-[2-(2-hydroxyethoxy)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	469-82-9 ;
PubChem CID	61122;
DrugBank	DB01505 ;
ChemSpider	55070 ;
UNII	RHW35E1G7E;
ChEMBL	ChEMBL2104254;
CompTox Dashboard (EPA)	DTXSID30196980 ;
ECHA InfoCard	100.006.750
Chemical and physical data
Formula	C18H27NO4
Molar mass	321.41 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1(CCN(CC1)CCOCCO)(C(=O)OCC)C2=CC=CC=C2;
	InChI InChI=1S/C18H27NO4/c1-2-23-17(21)18(16-6-4-3-5-7-16)8-10-19(11-9-18)12-14-22-15-13-20/h3-7,20H,2,8-15H2,1H3 ; Key:KJTKYGFGPQSRRA-UHFFFAOYSA-N ;
	(verify)

Etoxeridine (Carbetidine, Atenos) is a 4-phenyl piperidine derivative that is related to the opioid analgesic drug pethidine (meperidine).

Etoxeridine was developed in the 1950s^[1] and investigated for use in surgical anesthesia, however it was never commercialised and is not currently used in medicine.^[2]^[3]^[4]

References

^ BE Patent 558883
^ Merlevede E, Levis S. Pharmacological study of carbetidine, a new synthetic analgesic. (French). Archives Internationales de Pharmacodynamie et de Thérapie. 1958 May 1;115(1-2):213-32.
^ Sironi PG. Brief note on a new synthetic analgesic: carbetidine hydrochloride. (Italian). Minerva Anestesiologica. 1959 Jun;25(6):251-4.
^ Crawford JS, Foldes FF. Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia. British Journal of Anaesthesia. 1959 Aug;31:348-51.

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[1] BE Patent 558883

[2] Merlevede E, Levis S. Pharmacological study of carbetidine, a new synthetic analgesic. (French). Archives Internationales de Pharmacodynamie et de Thérapie. 1958 May 1;115(1-2):213-32.

[3] Sironi PG. Brief note on a new synthetic analgesic: carbetidine hydrochloride. (Italian). Minerva Anestesiologica. 1959 Jun;25(6):251-4.

[4] Crawford JS, Foldes FF. Studies on the respiratory and circulatory effects of carbetidine HCI used for supplementation of thiopentone sodium-nitrous oxide-oxygen anaesthesia. British Journal of Anaesthesia. 1959 Aug;31:348-51.

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