GABRA4

GABRA4
Identifiers
Aliases	GABRA4, gamma-aminobutyric acid type A receptor alpha4 subunit, gamma-aminobutyric acid type A receptor subunit alpha4
External IDs	OMIM: 137141; MGI: 95616; HomoloGene: 631; GeneCards: GABRA4; OMA:GABRA4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	46,993,581 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	71,658,308 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; entorhinal cortex; ; buccal mucosa cell; ; superior frontal gyrus; ; middle temporal gyrus; ; Brodmann area 23; ; lateral nuclear group of thalamus; ; nucleus accumbens; ; endothelial cell; ; caudate nucleus;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; olfactory tubercle; ; primary motor cortex; ; cingulate gyrus; ; piriform cortex; ; anterior amygdaloid area; ; nucleus accumbens; ; globus pallidus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; GABA-A receptor complex; postsynaptic membrane; membrane; synapse; integral component of plasma membrane; chloride channel complex; cell junction; plasma membrane; GABA-ergic synapse; integral component of postsynaptic specialization membrane; dendrite membrane; neuron projection; postsynapse;
Biological process	gamma-aminobutyric acid signaling pathway; chloride transmembrane transport; ion transport; regulation of response to drug; central nervous system development; chloride transport; ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2557
	14397
	ENSG00000109158
	ENSMUSG00000029211
	P48169
	Q9D6F4
	NM_000809; NM_001204266; NM_001204267
	NM_010251
	NP_000800; NP_001191195; NP_001191196
NP_034381; NP_001345970; NP_001345972; NP_001345973; NP_001345974;
	NP_001345975; NP_001345976; NP_001345977; NP_001345979
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid receptor subunit alpha-4 is a protein that in humans is encoded by the GABRA4 gene.^[5]^[6]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109158 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLean PJ, Farb DH, Russek SJ (Aug 1995). "Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster". Genomics. 26 (3): 580–6. doi:10.1016/0888-7543(95)80178-O. PMID 7607683.
^ "Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4".

External links

GABRA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109158 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029211 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7607683-5] McLean PJ, Farb DH, Russek SJ (Aug 1995). "Mapping of the alpha 4 subunit gene (GABRA4) to human chromosome 4 defines an alpha 2-alpha 4-beta 1-gamma 1 gene cluster: further evidence that modern GABAA receptor gene clusters are derived from an ancestral cluster". Genomics. 26 (3): 580–6. doi:10.1016/0888-7543(95)80178-O. PMID 7607683.

[entrez-6] "Entrez Gene: GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4".

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GABRA4

See also

References

Further reading

External links