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Metrifonate

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Metrifonate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
CAS Number
PubChem CID
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.000.137 Edit this at Wikidata
Chemical and physical data
FormulaC4H8Cl3O4P
Molar mass257.436 g/mol g·mol−1
3D model (JSmol)
  • COP(=O)(C(C(Cl)(Cl)Cl)O)OC
  (verify)

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.[1] it is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.[3]

References

  1. ^ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".
  2. ^ Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine. 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ López-Arrieta J, Schneider L (2008). López-Arrieta, Jess (ed.). "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.
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