Norwogonin

Norwogonin
Clinical data
Other names	5,7,8-Trihydroxyflavone; 5,7,8-THF
Identifiers
	IUPAC name 5,7,8-trihydroxy-2-phenylchromen-4-one;
CAS Number	4443-09-8;
PubChem CID	5281674;
ChemSpider	4444993;
UNII	70U0WT21IB;
KEGG	C10113;
ChEBI	CHEBI:7642;
ChEMBL	ChEMBL485250;
CompTox Dashboard (EPA)	DTXSID20196171 ;
Chemical and physical data
Formula	C15H10O5
Molar mass	270.24 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O;
	InChI InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H; Key:ZFKKRRMUPBBYRS-UHFFFAOYSA-N;

Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap).^[1] It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known 7,8-dihydroxyflavone (7,8-DHF).^[2]

References

^ Miyasaki, Yoko; Rabenstein, John D.; Rhea, Joshua; Crouch, Marie-Laure; Mocek, Ulla M.; Kittell, Patricia Emmett; Morgan, Margie A.; Nichols, Wesley Stephen; Van Benschoten, M. M.; Hardy, William David; Liu, George Y. (2013). Khan, Asad U (ed.). "Isolation and Characterization of Antimicrobial Compounds in Plant Extracts against Multidrug-Resistant Acinetobacter baumannii". PLoS ONE. 8 (4): e61594. doi:10.1371/journal.pone.0061594. PMC 3632535. PMID 23630600.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Liu, Xia; Chan, Chi-Bun; Jang, Sung-Wuk; Pradoldej, Sompol; Huang, Junjian; He, Kunyan; Phun, Lien H.; France, Stefan; Xiao, Ge; Jia, Yonghui; Luo, Hongbo R.; Ye, Keqiang (2010). "A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect". Journal of Medicinal Chemistry. 53 (23): 8274–8286. doi:10.1021/jm101206p. ISSN 0022-2623. PMC 3150605. PMID 21073191.