PTPN4

PTPN4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CS5, 2VPH, 3NFK, 3NFL, 2I75, 5EZ0, 5EYZ
Identifiers
Aliases	PTPN4, MEG, PTPMEG, PTPMEG1, protein tyrosine phosphatase, non-receptor type 4, protein tyrosine phosphatase non-receptor type 4
External IDs	OMIM: 176878; MGI: 1099792; HomoloGene: 2120; GeneCards: PTPN4; OMA:PTPN4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	119,984,899 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	119,837,613 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; granulocyte; ; cerebellar vermis; ; Achilles tendon; ; renal medulla; ; paraflocculus of cerebellum; ; Skeletal muscle tissue of rectus abdominis; ; corpus callosum; ; parietal lobe; ; pons;
	Top expressed in
	lateral geniculate nucleus; ; medial geniculate nucleus; ; medial dorsal nucleus; ; cerebellar vermis; ; lobe of cerebellum; ; Region I of hippocampus proper; ; triceps brachii muscle; ; spermatid; ; superior colliculus; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; cytoskeletal protein binding; protein binding; phosphoprotein phosphatase activity; hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity;
Cellular component	cytoplasm; cytoplasmic side of plasma membrane; plasma membrane; cytoskeleton; membrane; nucleoplasm; cytosol;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5775
	19258
	ENSG00000088179
	ENSMUSG00000026384
	P29074
	Q9WU22
	NM_002830
	NM_019933
	NP_002821
	NP_064317
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.^[6]

Interactions

PTPN4 has been shown to interact with GRID2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000088179 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026384 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. doi:10.1073/pnas.88.13.5867. PMC 51979. PMID 1648233.
^ ^a ^b "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".
^ Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Gu M, Majerus PW (1996). "The properties of the protein tyrosine phosphatase PTPMEG". J. Biol. Chem. 271 (44): 27751–9. doi:10.1074/jbc.271.44.27751. PMID 8910369.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gu M, Meng K, Majerus PW (1996). "The effect of overexpression of the protein tyrosine phosphatase PTPMEG on cell growth and on colony formation in soft agar in COS-7 cells". Proc. Natl. Acad. Sci. U.S.A. 93 (23): 12980–5. doi:10.1073/pnas.93.23.12980. PMC 24032. PMID 8917530.
Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933.
Park KW, Lee EJ, Lee S, Lee JE, Choi E, Kim BJ, Hwang R, Park KA, Baik J (2001). "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG". Gene. 257 (1): 45–55. doi:10.1016/S0378-1119(00)00351-6. PMID 11054567.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000088179 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026384 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1648233-5] Gu MX, York JD, Warshawsky I, Majerus PW (August 1991). "Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1". Proc Natl Acad Sci U S A. 88 (13): 5867–71. doi:10.1073/pnas.88.13.5867. PMC 51979. PMID 1648233.

[entrez-6] "Entrez Gene: PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)".

[pmid10748123-7] Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T (May 2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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Function

Interactions

References

Further reading