Polydiethylstilbestrol phosphate

From Wikipedia, the free encyclopedia
Polydiethylstilbestrol phosphate
Polydiethylstilbestrol phosphate.svg
Clinical data
Other namesPSP; PDSP; Diethylstilbestrol polymer with phosphoric acid; (E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis(phenol) polymer with phosphoric acid
Routes of
administration
Intramuscular injection
Drug classEstrogen; Nonsteroidal estrogen; Estrogen ester
Identifiers
CAS Number
Chemical and physical data
Formula(C18H19O4P)n

Polydiethylstilbestrol phosphate (PSP, PDSP) is an estrogen medication which has been used in scientific research and has been studied for use in veterinary medicine as a livestock growth promoter.[1][2][3][4][5][6] It is a phosphate ester of diethylstilbestrol (DES) in the form of a polymer and is a polymeric form of fosfestrol (diethylstilbestrol diphosphate); PDSP acts as a long-lasting prodrug of DES.[1] It has similarities to polyestradiol phosphate and polyestriol phosphate.[1]

See also[edit]

References[edit]

  1. ^ a b c Diczfalusy E, Fernö H, Fex B, Högberg B, Kneip P (1959). "High Molecular Weight Enzyme Inhibitors. IV. Polymeric Phosphates of Synthetic Estrogens" (PDF). Acta Chem. Scand. 13 (5): 1011–1018. doi:10.3891/acta.chem.scand.13-1011.
  2. ^ Bengtsson G, Ullberg S, Perklev T (August 1963). "Autoradiographic Distribution Studies after Administration of a Macromolecular Synthetic Oestrogen (14C-Polydiethylstilboestrol Phosphate)". Acta Endocrinol. 43 (4): 571–80. doi:10.1530/acta.0.0430571. PMID 14059878.
  3. ^ Perklev T (November 1964). "Distribution and Excretion of Radioactivity after Parenteral Administration of Radioactive Polydiethylstilbestrol Phosphate to Rats and a Cow". Proc. Soc. Exp. Biol. Med. 117 (2): 394–8. doi:10.3181/00379727-117-29590. PMID 14233451. S2CID 28242978.
  4. ^ Perklev T, Gassner FX, Martin RP, Huseby RA, Shimoda W (1965). "Excretion of radioactivity by human subjects after ingestion of liver from cattle treated with labeled polydiethylstilbestrol phosphate". Proc. Soc. Exp. Biol. Med. 119 (4): 996–8. doi:10.3181/00379727-119-30359. PMID 5891085. S2CID 43341013.
  5. ^ Perklev T, Gassner FX, Hopwood ML (September 1967). "Distribution and excretion of 14C-labeled polydiethylstilbestrol phosphate in a steer". J. Anim. Sci. 26 (5): 1094–100. doi:10.2527/jas1967.2651094x. PMID 6077168.
  6. ^ Loew FM (October 1972). "The veterinarian and intensive livestock production: humane considerations". Can. Vet. J. 13 (10): 229–33. PMC 1695928. PMID 4562986.