Interleukin 32: Difference between revisions
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'''Interleukin 32''' (IL-32) is a pro-inflammatory [[cytokine]] that can induce cells of the [[immune system]] (such as [[monocyte]]s and [[macrophage]]s) to secrete inflammatory cytokines, such as [[tumor necrosis factor-alpha]] (TNF-α) and IL-6. In addition, it can also induce the production of [[chemokines]] such as [[Interleukin 8|IL-8]] and [[MIP-2]]/CXCL2.<ref>Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA |
'''Interleukin 32''' (IL-32) is a pro-inflammatory [[cytokine]] that can induce cells of the [[immune system]] (such as [[monocyte]]s and [[macrophage]]s) to secrete inflammatory cytokines, such as [[tumor necrosis factor-alpha]] (TNF-α) and IL-6. In addition, it can also induce the production of [[chemokines]] such as [[Interleukin 8|IL-8]] and [[MIP-2]]/CXCL2.<ref name="pmid15664165">{{cite journal | author = Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA | title = Interleukin-32: a cytokine and inducer of TNFalpha | journal = Immunity | volume = 22 | issue = 1 | pages = 131–42 | year = 2005 | month = January | pmid = 15664165 | doi = 10.1016/j.immuni.2004.12.003 }}</ref> |
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IL-32 can also support [[osteoclast]] differentiation but not osteoclast activation by regulating the [[MAPK/ERK pathway]] and the actin cytoskeleton. |
IL-32 can also support [[osteoclast]] differentiation but not osteoclast activation by regulating the [[MAPK/ERK pathway]] and the actin cytoskeleton.<ref name="pmid19137064">{{cite journal | author = Mabilleau G, Sabokbar A | title = Interleukin-32 promotes osteoclast differentiation but not osteoclast activation | journal = PLoS ONE | volume = 4 | issue = 1 | pages = e4173 | year = 2009 | pmid = 19137064 | pmc = 2613539 | doi = 10.1371/journal.pone.0004173 }}</ref> |
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== References == |
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Revision as of 08:18, 14 September 2013
| Interleukin 32 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL32 | ||||||
| Alt. symbols | , NK4, TAIF, TAIFb, TAIFd | ||||||
| NCBI gene | 9235 | ||||||
| HGNC | 16830 | ||||||
| OMIM | 606001 | ||||||
| RefSeq | NM_004221 | ||||||
| UniProt | P24001 | ||||||
| Other data | |||||||
| Locus | Chr. 16 p13.3 | ||||||
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Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2/CXCL2.[1]
IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.[2]
References
- ^ Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (2005). "Interleukin-32: a cytokine and inducer of TNFalpha". Immunity. 22 (1): 131–42. doi:10.1016/j.immuni.2004.12.003. PMID 15664165.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Mabilleau G, Sabokbar A (2009). "Interleukin-32 promotes osteoclast differentiation but not osteoclast activation". PLoS ONE. 4 (1): e4173. doi:10.1371/journal.pone.0004173. PMC 2613539. PMID 19137064.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
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