CXCL16

From Wikipedia, the free encyclopedia
Jump to: navigation, search
chemokine (C-X-C motif) ligand 16
Identifiers
Symbol CXCL16
Alt. symbols SCYB16, SR-PSOX, CXCLG16
Entrez 58191
HUGO 16642
OMIM 605398
RefSeq NM_022059
UniProt Q9H2A7
Other data
Locus Chr. 17 p13

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.[1] These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine.[2] CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen.[1] Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.[1] CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo.[1][3] Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha.[2] The gene for human CXCL16 is located on chromosome 17.[1]

The administration of fololinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues. Colonization of neonatal GF mice, but not in adult mice, with a conventional microbiota decreases hypermethylation levels of CXCL 16.

References[edit]

  1. ^ a b c d e Matloubian M, David A, Engel S, Ryan J, Cyster J (2000). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo". Nat Immunol 1 (4): 298–304. doi:10.1038/79738. PMID 11017100. 
  2. ^ a b Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen K, Saftig P, Rose-John S, Ludwig A (2004). "The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10". J Immunol 172 (10): 6362–72. doi:10.4049/jimmunol.172.10.6362. PMID 15128827. 
  3. ^ Wilbanks A, Zondlo S, Murphy K, Mak S, Soler D, Langdon P, Andrew D, Wu L, Briskin M (2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines". J Immunol 166 (8): 5145–54. doi:10.4049/jimmunol.166.8.5145. PMID 11290797.