CCL1

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chemokine (C-C motif) ligand 1
Identifiers
Symbol CCL1
Alt. symbols SCYA1, I-309, TCA3, P500, SISe
Entrez 6346
HUGO 10609
OMIM 182281
PDB 1EL0 (RCSB PDB PDBe PDBj)
RefSeq NM_002981
UniProt P22362
Other data
Locus Chr. 17 q11.2

Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines.[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17.

References[edit]

  1. ^ Miller MD, Krangel MS (April 1992). "The human cytokine I-309 is a monocyte chemoattractant". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2950–4. doi:10.1073/pnas.89.7.2950. PMC 48781. PMID 1557400. 
  2. ^ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.