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Chemokine (C-X-C motif) ligand 9
Symbols CXCL9 ; CMK; Humig; MIG; SCYB9; crg-10
External IDs OMIM601704 MGI1352449 HomoloGene1813 GeneCards: CXCL9 Gene
RNA expression pattern
PBB GE CXCL9 203915 at tn.png
More reference expression data
Species Human Mouse
Entrez 4283 17329
Ensembl ENSG00000138755 ENSMUSG00000029417
UniProt Q07325 P18340
RefSeq (mRNA) NM_002416 NM_008599
RefSeq (protein) NP_002407 NP_032625
Location (UCSC) Chr 4:
76.92 – 76.93 Mb
Chr 5:
92.32 – 92.33 Mb
PubMed search [1] [2]

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on human chromosome 4.[1][2] CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the chemokine receptor CXCR3.[3]

Neutrophil collagenase/matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.

Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.


CXCL9 has been shown to interact with CXCR3.[4][5]


  1. ^ Lee HH, Farber JM (1996). "Localization of the gene for the human MIG cytokine on chromosome 4q21 adjacent to INP10 reveals a chemokine "mini-cluster"". Cytogenet. Cell Genet. 74 (4): 255–8. doi:10.1159/000134428. PMID 8976378. 
  2. ^ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet. Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. 
  3. ^ Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R (1999). "Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)". J. Invest. Dermatol. 112 (5): 716–22. doi:10.1046/j.1523-1747.1999.00581.x. PMID 10233762. 
  4. ^ Lasagni, Laura; Francalanci Michela, Annunziato Francesco, Lazzeri Elena, Giannini Stefano, Cosmi Lorenzo, Sagrinati Costanza, Mazzinghi Benedetta, Orlando Claudio, Maggi Enrico, Marra Fabio, Romagnani Sergio, Serio Mario, Romagnani Paola (Jun 2003). "An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4". J. Exp. Med. (United States) 197 (11): 1537–49. doi:10.1084/jem.20021897. ISSN 0022-1007. PMC 2193908. PMID 12782716. 
  5. ^ Weng, Y; Siciliano S J; Waldburger K E; Sirotina-Meisher A; Staruch M J; Daugherty B L; Gould S L; Springer M S; DeMartino J A (Jul 1998). "Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors". J. Biol. Chem. (UNITED STATES) 273 (29): 18288–91. doi:10.1074/jbc.273.29.18288. ISSN 0021-9258. PMID 9660793. 

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