CCL12

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Chemokine (C-C motif) ligand 12
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols Ccl12 ; MCP-5; Scya12
External IDs OMIM158105 HomoloGene2245 GeneCards: Ccl12 Gene
Orthologs
Species Human Mouse
Entrez 20293 20293
Ensembl ENSMUSG00000035352 ENSMUSG00000035352
UniProt Q62401 Q62401
RefSeq (mRNA) NM_011331 NM_011331
RefSeq (protein) NP_035461 NP_035461
Location (UCSC) Chr 11:
82.1 – 82.1 Mb
Chr 11:
82.1 – 82.1 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes.[1] This chemokine is found predominately in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages.[1][2] It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.[2]

References[edit]

  1. ^ a b Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876. PMID 8920881. 
  2. ^ a b Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097. PMID 8996246.