CDC14A

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Cell division cycle 14A
Identifiers
Symbols CDC14A ; cdc14; hCDC14
External IDs OMIM603504 MGI2442676 HomoloGene75343 ChEMBL: 1772926 GeneCards: CDC14A Gene
EC number 3.1.3.16, 3.1.3.48
RNA expression pattern
PBB GE CDC14A 210743 s at tn.png
PBB GE CDC14A 210742 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8556 229776
Ensembl ENSG00000079335 ENSMUSG00000033502
UniProt Q9UNH5 Q6GQT0
RefSeq (mRNA) NM_003672 NM_001080818
RefSeq (protein) NP_003663 NP_001074287
Location (UCSC) Chr 1:
100.35 – 100.52 Mb
Chr 3:
116.27 – 116.42 Mb
PubMed search [1] [2]

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.[1][2][3]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.[3]

Interactions[edit]

CDC14A has been shown to interact with P53.[4]

References[edit]

  1. ^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem 272 (47): 29403–6. doi:10.1074/jbc.272.47.29403. PMID 9367992. 
  2. ^ Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (September 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics 59 (2): 248–51. doi:10.1006/geno.1999.5863. PMID 10409437. 
  3. ^ a b "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)". 
  4. ^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. (UNITED STATES) 275 (4): 2410–4. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693. 

Further reading[edit]