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Protein tyrosine phosphatase, receptor type, H
Symbols PTPRH ; R-PTP-H; SAP1
External IDs OMIM602510 HomoloGene37693 IUPHAR: 1857 GeneCards: PTPRH Gene
EC number
RNA expression pattern
PBB GE PTPRH 208300 at tn.png
More reference expression data
Species Human Mouse
Entrez 5794 545902
Ensembl ENSG00000080031 ENSMUSG00000035429
UniProt Q9HD43 E9Q0N2
RefSeq (mRNA) NM_001161440 NM_207270
RefSeq (protein) NP_001154912 NP_997153
Location (UCSC) Chr 19:
55.69 – 55.72 Mb
Chr 7:
4.55 – 4.6 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[2]


  1. ^ Matozaki T, Suzuki T, Uchida T, Inazawa J, Ariyama T, Matsuda K, Horita K, Noguchi H, Mizuno H, Sakamoto C et al. (Feb 1994). "Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers". J Biol Chem 269 (3): 2075–81. PMID 8294459. 
  2. ^ a b "Entrez Gene: PTPRH protein tyrosine phosphatase, receptor type, H". 

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