EYA2

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EYA transcriptional coactivator and phosphatase 2
Protein EYA2 PDB 3GEB.png
Rendering based on PDB 3GEB.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EYA2 ; EAB1
External IDs OMIM601654 MGI109341 HomoloGene40711 ChEMBL: 1293275 GeneCards: EYA2 Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE EYA2 209692 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2139 14049
Ensembl ENSG00000064655 ENSMUSG00000017897
UniProt O00167 O08575
RefSeq (mRNA) NM_005244 NM_001271962
RefSeq (protein) NP_005235 NP_001258891
Location (UCSC) Chr 20:
45.52 – 45.82 Mb
Chr 2:
165.6 – 165.77 Mb
PubMed search [1] [2]

Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene.[1][2]

Function[edit]

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.[2]

Interactions[edit]

EYA2 has been shown to interact with GNAI2[3] and GNAZ.[3]

References[edit]

  1. ^ Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C et al. (Feb 1997). "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family". Nature Genetics 15 (2): 157–64. doi:10.1038/ng0297-157. PMID 9020840. 
  2. ^ a b "Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila)". 
  3. ^ a b Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (Oct 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". The Journal of Biological Chemistry 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137. 

Further reading[edit]

  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Zimmerman JE, Bui QT, Steingrímsson E, Nagle DL, Fu W, Genin A et al. (Feb 1997). "Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene". Genome Research 7 (2): 128–41. doi:10.1101/gr.7.2.128. PMID 9049631. 
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W et al. (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. 
  • Duncan MK, Kos L, Jenkins NA, Gilbert DJ, Copeland NG, Tomarev SI (Jul 1997). "Eyes absent: a gene family found in several metazoan phyla". Mammalian Genome 8 (7): 479–85. doi:10.1007/s003359900480. PMID 9195991. 
  • Borsani G, DeGrandi A, Ballabio A, Bulfone A, Bernard L, Banfi S et al. (Jan 1999). "EYA4, a novel vertebrate gene related to Drosophila eyes absent". Human Molecular Genetics 8 (1): 11–23. doi:10.1093/hmg/8.1.11. PMID 9887327. 
  • Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (Oct 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". The Journal of Biological Chemistry 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137. 
  • Clark SW, Fee BE, Cleveland JL (Feb 2002). "Misexpression of the eyes absent family triggers the apoptotic program". The Journal of Biological Chemistry 277 (5): 3560–7. doi:10.1074/jbc.M108410200. PMID 11700312. 
  • Fee BE, Doyle CA, Cleveland JL (Feb 2002). "A novel Eyes Absent 2 protein is expressed in the human eye". Gene 285 (1-2): 221–8. doi:10.1016/S0378-1119(02)00404-3. PMID 12039049. 
  • Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C et al. (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". Journal of Muscle Research and Cell Motility 23 (3): 255–64. doi:10.1023/A:1020990825644. PMID 12500905. 
  • Zhang L, Yang N, Huang J, Buckanovich RJ, Liang S, Barchetti A et al. (Feb 2005). "Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth". Cancer Research 65 (3): 925–32. PMID 15705892. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.