From Wikipedia, the free encyclopedia
Jump to: navigation, search
EYA transcriptional coactivator and phosphatase 2
Protein EYA2 PDB 3GEB.png
Rendering based on PDB 3GEB.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EYA2 ; EAB1
External IDs OMIM601654 MGI109341 HomoloGene40711 ChEMBL: 1293275 GeneCards: EYA2 Gene
EC number
RNA expression pattern
PBB GE EYA2 209692 at tn.png
More reference expression data
Species Human Mouse
Entrez 2139 14049
Ensembl ENSG00000064655 ENSMUSG00000017897
UniProt O00167 O08575
RefSeq (mRNA) NM_005244 NM_001271962
RefSeq (protein) NP_005235 NP_001258891
Location (UCSC) Chr 20:
45.52 – 45.82 Mb
Chr 2:
165.6 – 165.77 Mb
PubMed search [1] [2]

Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene.[1][2]

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.[2]


EYA2 has been shown to interact with GNAI2[3] and GNAZ.[3]


  1. ^ Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C (March 1997). "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family". Nat Genet 15 (2): 157–64. doi:10.1038/ng0297-157. PMID 9020840. 
  2. ^ a b "Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila)". 
  3. ^ a b Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. (UNITED STATES) 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137. 

Further reading[edit]