From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein tyrosine phosphatase, receptor type, N
Protein PTPRN PDB 2i1y.png
PDB rendering based on 2i1y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTPRN ; IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
External IDs OMIM601773 MGI102765 HomoloGene48142 IUPHAR: 1861 GeneCards: PTPRN Gene
EC number
RNA expression pattern
PBB GE PTPRN 204945 at tn.png
More reference expression data
Species Human Mouse
Entrez 5798 19275
Ensembl ENSG00000054356 ENSMUSG00000026204
UniProt Q16849 Q60673
RefSeq (mRNA) NM_001199763 NM_008985
RefSeq (protein) NP_001186692 NP_033011
Location (UCSC) Chr 2:
220.15 – 220.17 Mb
Chr 1:
75.25 – 75.26 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.[1][2]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.[2]


PTPRN has been shown to interact with SPTBN4.[3]


  1. ^ Lan MS, Lu J, Goto Y, Notkins AL (August 1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol 13 (5): 505–14. doi:10.1089/dna.1994.13.505. PMID 8024693. 
  2. ^ a b "Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N". 
  3. ^ Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM et al. (November 2000). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001. 

Further reading[edit]