PTPN7

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Protein tyrosine phosphatase, non-receptor type 7
Protein PTPN7 PDB 1zc0.png
PDB rendering based on 1zc0.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PTPN7 ; BPTP-4; HEPTP; LC-PTP; LPTP; PTPNI
External IDs OMIM176889 MGI2156893 HomoloGene15411 ChEMBL: 2219 GeneCards: PTPN7 Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE PTPN7 204852 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5778 320139
Ensembl ENSG00000143851 ENSMUSG00000031506
UniProt P35236 Q8BUM3
RefSeq (mRNA) NM_001199797 NM_177081
RefSeq (protein) NP_001186726 NP_796055
Location (UCSC) Chr 1:
202.12 – 202.13 Mb
Chr 1:
135.13 – 135.15 Mb
PubMed search [1] [2]

Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[2]

Interactions[edit]

PTPN7 has been shown to interact with MAPK3[3][4][5] and MAPK1.[3][5]

References[edit]

  1. ^ Adachi M, Sekiya M, Isobe M, Kumura Y, Ogita Z, Hinoda Y, Imai K, Yachi A (September 1992). "Molecular cloning and chromosomal mapping of a human protein-tyrosine phosphatase LC-PTP". Biochem Biophys Res Commun 186 (3): 1607–15. doi:10.1016/S0006-291X(05)81592-X. PMID 1510684. 
  2. ^ a b "Entrez Gene: PTPN7 protein tyrosine phosphatase, non-receptor type 7". 
  3. ^ a b Pettiford, S M; Herbst R (February 2000). "The MAP-kinase ERK2 is a specific substrate of the protein tyrosine phosphatase HePTP". Oncogene (ENGLAND) 19 (7): 858–69. doi:10.1038/sj.onc.1203408. ISSN 0950-9232. PMID 10702794. 
  4. ^ Saxena, M; Williams S; Taskén K; Mustelin T (September 1999). "Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase". Nat. Cell Biol. (ENGLAND) 1 (5): 305–11. doi:10.1038/13024. ISSN 1465-7392. PMID 10559944. 
  5. ^ a b Saxena, M; Williams S; Brockdorff J; Gilman J; Mustelin T (April 1999). "Inhibition of T cell signaling by mitogen-activated protein kinase-targeted hematopoietic tyrosine phosphatase (HePTP)". J. Biol. Chem. (UNITED STATES) 274 (17): 11693–700. doi:10.1074/jbc.274.17.11693. ISSN 0021-9258. PMID 10206983. 

Further reading[edit]