MTMR9

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Myotubularin related protein 9
Identifiers
Symbols MTMR9 ; C8orf9; LIP-STYX; MTMR8
External IDs OMIM606260 MGI2442842 HomoloGene9148 GeneCards: MTMR9 Gene
RNA expression pattern
PBB GE MTMR9 204837 at tn.png
PBB GE MTMR9 213278 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 66036 210376
Ensembl ENSG00000104643 ENSMUSG00000035078
UniProt Q96QG7 Q9Z2D0
RefSeq (mRNA) NM_015458 NM_177594
RefSeq (protein) NP_056273 NP_808262
Location (UCSC) Chr 8:
11.14 – 11.19 Mb
Chr 14:
63.52 – 63.54 Mb
PubMed search [1] [2]

Myotubularin-related protein 9 is a protein that in humans is encoded by the MTMR9 gene.[1][2][3][4]

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.[4]

Interactions[edit]

MTMR9 has been shown to interact with MTMR6.[3]

References[edit]

  1. ^ Appel S, Reichwald K, Zimmermann W, Reis A, Rosenthal A, Hennies HC (Jul 2001). "Identification and localization of a new human myotubularin-related protein gene, mtmr8, on 8p22-p23". Genomics 75 (1–3): 6–8. doi:10.1006/geno.2001.6591. PMID 11472061. 
  2. ^ Appel S, Filter M, Reis A, Hennies HC, Bergheim A, Ogilvie E, Arndt S, Simmons A, Lovett M, Hide W, Ramsay M, Reichwald K, Zimmermann W, Rosenthal A (Mar 2002). "Physical and transcriptional map of the critical region for keratolytic winter erythema (KWE) on chromosome 8p22-p23 between D8S550 and D8S1759". Eur J Hum Genet 10 (1): 17–25. doi:10.1038/sj.ejhg.5200750. PMID 11896452. 
  3. ^ a b Mochizuki Y, Majerus PW (Aug 2003). "Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9". Proc Natl Acad Sci U S A 100 (17): 9768–9773. doi:10.1073/pnas.1333958100. PMC 187840. PMID 12890864. 
  4. ^ a b "Entrez Gene: MTMR9 myotubularin related protein 9". 

Further reading[edit]