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Protein tyrosine phosphatase, receptor type, B
Protein PTPRB PDB 2ahs.png
PDB rendering based on 2ahs.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176882 MGI97809 HomoloGene2125 ChEMBL: 2706 GeneCards: PTPRB Gene
EC number
RNA expression pattern
PBB GE PTPRB 205846 at tn.png
More reference expression data
Species Human Mouse
Entrez 5787 19263
Ensembl ENSG00000127329 ENSMUSG00000020154
UniProt P23467 B2RU80
RefSeq (mRNA) NM_001109754 NM_029928
RefSeq (protein) NP_001103224 NP_084204
Location (UCSC) Chr 12:
70.91 – 71.03 Mb
Chr 10:
116.3 – 116.39 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase beta is an enzyme that in humans is encoded by the PTPRB gene.[1][2]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation.[2]


PTPRB has been shown to interact with CNTN1,[3][4] MAGI3[5] and VE-cadherin.[6]


  1. ^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M et al. (Oct 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc Natl Acad Sci U S A 87 (18): 7000–4. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617. 
  2. ^ a b "Entrez Gene: PTPRB protein tyrosine phosphatase, receptor type, B". 
  3. ^ Sakurai T, Lustig M, Nativ M, Hemperly J, Schlessinger J, Peles E et al. (Feb 1997). "Induction of Neurite Outgrowth through Contactin and Nr-CAM by Extracellular Regions of Glial Receptor Tyrosine Phosphatase β". J. Cell Biol. 136 (4): 907–18. doi:10.1083/jcb.136.4.907. PMC 2132488. PMID 9049255. 
  4. ^ Peles E, Nativ M, Campbell P, Sakurai T, Martinez R, Lev S et al. (Jul 1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell 82 (2): 251–60. doi:10.1016/0092-8674(95)90312-7. PMID 7628014. 
  5. ^ Adamsky K, Arnold K, Sabanay H, Peles E (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell. Sci. 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. PMID 12615970. 
  6. ^ Nawroth R, Poell G, Ranft A, Kloep S, Samulowitz U, Fachinger G et al. (Sep 2002). "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts". EMBO J. 21 (18): 4885–95. doi:10.1093/emboj/cdf497. PMC 126293. PMID 12234928. 

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