M6PRBP1

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Perilipin 3
Identifiers
Symbols PLIN3 ; M6PRBP1; PP17; TIP47
External IDs OMIM602702 MGI1914155 HomoloGene4247 GeneCards: PLIN3 Gene
RNA expression pattern
PBB GE M6PRBP1 202122 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10226 66905
Ensembl ENSG00000105355 ENSMUSG00000024197
UniProt O60664 Q9DBG5
RefSeq (mRNA) NM_001164189 NM_025836
RefSeq (protein) NP_001157661 NP_080112
Location (UCSC) Chr 19:
4.84 – 4.87 Mb
Chr 17:
56.28 – 56.29 Mb
PubMed search [1] [2]

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene.[1] Its gene product, as well as the gene itself, is commonly known as TIP47.

Function[edit]

Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.[2]

The mannose-6-phosphate receptor-binding properties of TIP47 are disputed,[3] despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for lipid droplets.[4]

TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including perilipin and adipophilin.[5]

Interactions[edit]

M6PRBP1 has been shown to interact with both Mannose 6-phosphate receptors.[6][7]

References[edit]

  1. ^ "Entrez Gene: M6PRBP1 mannose-6-phosphate receptor binding protein 1". 
  2. ^ Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR. (May 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.". Science 292 (5520): 1373–6. doi:10.1126/science.1056791. PMID 11359012. 
  3. ^ Bulankina AV, Deggerich A, Wenzel D, Mutenda K, Wittmann JG, Rudolph MG, Burger KN, Höning S (May 2009). "TIP47 functions in the biogenesis of lipid droplets". J. Cell Biol. 185 (4): 641–55. doi:10.1083/jcb.200812042. PMC 2711566. PMID 19451273. 
  4. ^ Ducharme NA, Bickel PE (March 2008). "Lipid droplets in lipogenesis and lipolysis". Endocrinology 149 (3): 942–9. doi:10.1210/en.2007-1713. PMID 18202123. 
  5. ^ Brasaemle DL (December 2007). "Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis". J. Lipid Res. 48 (12): 2547–59. doi:10.1194/jlr.R700014-JLR200. PMID 17878492. 
  6. ^ Díaz, E; Pfeffer S R (May 1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking". Cell (UNITED STATES) 93 (3): 433–43. doi:10.1016/S0092-8674(00)81171-X. ISSN 0092-8674. PMID 9590177. 
  7. ^ Orsel, J G; Sincock P M; Krise J P; Pfeffer S R (August 2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9047–51. doi:10.1073/pnas.160251397. ISSN 0027-8424. PMC 16819. PMID 10908666. 

Further reading[edit]

External links[edit]