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Syntaxin 7
Protein STX7 PDB 1gl2.png
PDB rendering based on 1gl2.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol STX7
External IDs OMIM603217 MGI1858210 HomoloGene37823 GeneCards: STX7 Gene
RNA expression pattern
PBB GE STX7 203457 at tn.png
PBB GE STX7 212631 at tn.png
PBB GE STX7 212632 at tn.png
More reference expression data
Species Human Mouse
Entrez 8417 53331
Ensembl ENSG00000079950 ENSMUSG00000019998
UniProt O15400 Q8BH40
RefSeq (mRNA) NM_003569 NM_016797
RefSeq (protein) NP_003560 NP_058077
Location (UCSC) Chr 6:
132.77 – 132.83 Mb
Chr 10:
24.15 – 24.19 Mb
PubMed search [1] [2]

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.[1][2]

In melanocytic cells STX7 gene expression may be regulated by MITF.[3]


STX7 has been shown to interact with STX8,[4] VPS18,[5] Vesicle-associated membrane protein 8[4][6] and VPS11.[5]


  1. ^ Wang H, Frelin L, Pevsner J (November 1997). "Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes". Gene 199 (1–2): 39–48. doi:10.1016/S0378-1119(97)00343-0. PMID 9358037. 
  2. ^ "Entrez Gene: STX7 syntaxin 7". 
  3. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  4. ^ a b Antonin, W; Holroyd C; Fasshauer D; Pabst S; Von Mollard G F; Jahn R (Dec 2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. (ENGLAND) 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. ISSN 0261-4189. PMC 305878. PMID 11101518. 
  5. ^ a b Kim, B Y; Krämer H; Yamamoto A; Kominami E; Kohsaka S; Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. (United States) 276 (31): 29393–402. doi:10.1074/jbc.M101778200. ISSN 0021-9258. PMID 11382755. 
  6. ^ Wade, N; Bryant N J; Connolly L M; Simpson R J; Luzio J P; Piper R C; James D E (June 2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. (United States) 276 (23): 19820–7. doi:10.1074/jbc.M010838200. ISSN 0021-9258. PMID 11278762. 

Further reading[edit]