DUSP13

DUSP13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GWO, 2PQ5
Identifiers
Aliases	DUSP13, BEDP, DUSP13A, DUSP13B, MDSP, SKRP4, TMDP, dual specificity phosphatase 13
External IDs	OMIM: 613191; MGI: 1351599; HomoloGene: 121602; GeneCards: DUSP13; OMA:DUSP13 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q22.2 Start 75,094,432 bp End 75,109,221 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A3 Start 21,783,462 bp End 21,801,249 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle triceps brachii muscle glutes Skeletal muscle tissue of rectus abdominis biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii thoracic diaphragm deltoid muscle Top expressed in spermatid muscle of thigh triceps brachii muscle seminiferous tubule temporal muscle skeletal muscle tissue extraocular muscle sternocleidomastoid muscle medial head of gastrocnemius muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity phosphoprotein phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity phosphatase activity protein binding Cellular component cytoplasm Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation dephosphorylation spermatogenesis meiosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51207 27389 Ensembl ENSG00000079393 ENSMUSG00000021768 UniProt Q6B8I1 Q9UII6 Q6B8I0 Q9QYJ7 RefSeq (mRNA) NM_001007271 NM_001007272 NM_001007273 NM_001007274 NM_001007275 NM_016364 NM_001320842 NM_001320843 NM_001363514 NM_001007268 NM_013849 NM_001374075 NM_001374077 NM_001374078 NM_001374079 RefSeq (protein) NP_001007272 NP_001007273 NP_001007274 NP_001307771 NP_001307772 NP_057448 NP_001350443 NP_057448.3 NP_001307772.1 NP_001007269 NP_038877 NP_001361004 NP_001361006 NP_001361007 NP_001361008 NP_038877.2 Location (UCSC) Chr 10: 75.09 – 75.11 Mb Chr 14: 21.78 – 21.8 Mb PubMed search
Wikidata
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Dual specificity phosphatase 13 is an enzyme that in humans is encoded by the DUSP13 gene.

Function

Members of the protein tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This superfamily is separated into two families based on the substrate that is dephosphorylated. One family, the dual specificity phosphatases (DSPs) acts on both phosphotyrosine and phosphoserine/threonine residues. This gene encodes different but related DSP proteins through the use of non-overlapping open reading frames, alternate splicing, and presumed different transcription promoters. Expression of the distinct proteins from this gene has been found to be tissue specific and the proteins may be involved in postnatal development of specific tissues. A protein encoded by the upstream ORF was found in skeletal muscle, whereas the encoded protein from the downstream ORF was found only in testis. In mouse, a similar pattern of expression was found. Multiple alternatively spliced transcript variants were described, but the full-length sequence of only some were determined.

Further reading

• Nakamura K, Shima H, Watanabe M, et al. (2000). "Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis". Biochem. J. 344 Pt 3 (Pt 3): 819–25. doi:10.1042/0264-6021:3440819. PMC 1220704. PMID 10585869.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Chen HH, Luche R, Wei B, Tonks NK (2004). "Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2". J. Biol. Chem. 279 (40): 41404–13. doi:10.1074/jbc.M405286200. PMID 15252030.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kim SJ, Jeong DG, Yoon TS, et al. (2007). "Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity". Proteins. 66 (1): 239–45. doi:10.1002/prot.21197. PMID 17044055. S2CID 30555597.