CDC34

CDC34
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OB4, 3RZ3, 4MDK
Identifiers
Aliases	CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDs	OMIM: 116948; MGI: 102657; HomoloGene: 55815; GeneCards: CDC34; OMA:CDC34 - orthologs
EC number	2.3.2.24
Gene location (Human)
Chr.	Chromosome 19 (human)
End	542,092 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,524,232 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; apex of heart; ; ventricular zone; ; right hemisphere of cerebellum; ; muscle layer of sigmoid colon; ; muscle of thigh; ; ganglionic eminence; ; right lobe of liver; ; gastrocnemius muscle;
	Top expressed in
	quadriceps femoris muscle; ; muscle of thigh; ; muscle tissue; ; skeletal muscle tissue; ; epiblast; ; testicle; ; placenta; ; lip; ; white adipose tissue; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ubiquitin protein ligase activity; ubiquitin-protein transferase activity; protein binding; ATP binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding;
Cellular component	nucleus; nucleoplasm; cytoplasm; cytosol; nuclear speck;
Biological process	negative regulation of cAMP-mediated signaling; cellular response to interferon-beta; protein polyubiquitination; positive regulation of inclusion body assembly; protein K48-linked ubiquitination; positive regulation of neuron apoptotic process; DNA replication initiation; cell cycle; response to growth factor; proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; G1/S transition of mitotic cell cycle; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	997
	216150
	ENSG00000099804
	ENSMUSG00000020307
	P49427
	Q8CFI2
	NM_004359
	NM_177613; NM_001359817; NM_001359818
	NP_004350
	NP_808281; NP_001346746; NP_001346747
	Wikidata
View/Edit Human	View/Edit Mouse

CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.^[7]

Interactions

CDC34 has been shown to interact with CSNK2B,^[8] BTRC^[9]^[10] and CDK9.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099804 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020307 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
^ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
^ ^a ^b "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
^ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. 276 (44). United States: 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811.
^ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25). England: 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680.
^ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20). ENGLAND: 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035.
^ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23). United States: 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688.

External links

Human CDC34 genome location and CDC34 gene details page in the UCSC Genome Browser.

King RW, Deshaies RJ, Peters JM, Kirschner MW (1997). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. Bibcode:1996Sci...274.1652K. doi:10.1126/science.274.5293.1652. PMID 8939846.
Pagano M (1997). "Cell cycle regulation by the ubiquitin pathway". FASEB J. 11 (13): 1067–75. PMID 9367342.
Lisztwan J, Marti A, Sutterlüty H, et al. (1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". EMBO J. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
Song A, Wang Q, Goebl MG, Harrington MA (1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation". Mol. Cell. Biol. 18 (9): 4994–9. PMC 109084. PMID 9710583.
Gonen H, Bercovich B, Orian A, et al. (1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". J. Biol. Chem. 274 (21): 14823–30. doi:10.1074/jbc.274.21.14823. PMID 10329681.
Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Mol. Cell. Biol. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
Seol JH, Feldman RM, Zachariae W, et al. (1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34". Genes Dev. 13 (12): 1614–26. doi:10.1101/gad.13.12.1614. PMC 316801. PMID 10385629.
Read MA, Brownell JE, Gladysheva TB, et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Mol. Cell. Biol. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
Reymond F, Wirbelauer C, Krek W (2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase". J. Cell Sci. 113 (10): 1687–94. PMID 10769200.
Charrasse S, Carena I, Brondani V, et al. (2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway". Oncogene. 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
Strack P, Caligiuri M, Pelletier M, et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
Duan W, Sun B, Li TW, et al. (2001). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1–2): 113–21. doi:10.1016/S0378-1119(00)00365-6. PMID 11054541.
Block K, Boyer TG, Yew PR (2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
Wu K, Chen A, Tan P, Pan ZQ (2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34". J. Biol. Chem. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
Kiernan RE, Emiliani S, Nakayama K, et al. (2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
Semplici F, Meggio F, Pinna LA, Oliviero S (2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8248134-5] Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.

[pmid16210246-6] Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.

[entrez-7] "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".

[pmid11546811-8] Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. 276 (44). United States: 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811.

[pmid12037680-9] Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25). England: 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680.

[pmid10531035-10] Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20). ENGLAND: 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035.

[pmid11689688-11] Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. 21 (23). United States: 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688.

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Interactions

References

External links

Further reading