USP6

USP6
Identifiers
Aliases	USP6, HRP1, TRE17, TRE2, TRESMCR, Tre-2, USP6-short, ubiquitin specific peptidase 6
External IDs	OMIM: 604334; HomoloGene: 136783; GeneCards: USP6; OMA:USP6 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 5,116,032 bp End 5,175,034 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 sperm dorsal motor nucleus of vagus nerve Region I of hippocampus proper inferior olivary nucleus glutes Skeletal muscle tissue of biceps brachii middle temporal gyrus subthalamic nucleus endothelial cell n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type endopeptidase activity cysteine-type peptidase activity protein binding hydrolase activity nucleic acid binding GTPase activator activity calmodulin binding Cellular component cytoplasm recycling endosome endosome plasma membrane lysosome membrane Biological process protein deubiquitination regulation of vesicle-mediated transport ubiquitin-dependent protein catabolic process proteolysis intracellular protein transport regulation of vesicle fusion activation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9098 n/a Ensembl ENSG00000129204 n/a UniProt P35125 n/a RefSeq (mRNA) NM_001304284 NM_004505 NM_005152 n/a RefSeq (protein) NP_001291213 NP_004496 n/a Location (UCSC) Chr 17: 5.12 – 5.18 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Ubiquitin carboxyl-terminal hydrolase 6 is an enzyme that in humans is encoded by the USP6 gene.

Aneurysmal bone cyst can be associated with a TRE17/USP6 translocation.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Nakamura T, Hillova J, Mariage-Samson R, et al. (1992). "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells". Oncogene. 7 (4): 733–41. PMID 1565468.
• Papa FR, Hochstrasser M (1993). "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene". Nature. 366 (6453): 313–9. doi:10.1038/366313a0. PMID 8247125. S2CID 4273807.
• Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID 8406013.
• Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID 8471161.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMC 151371. PMID 12604796.
• Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC 149457. PMID 12612085.
• Bizimungu C, De Neve N, Burny A, et al. (2003). "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene". Biochem. Biophys. Res. Commun. 310 (2): 498–504. doi:10.1016/j.bbrc.2003.09.051. PMID 14521938.
• Oliveira AM, Hsi BL, Weremowicz S, et al. (2004). "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst". Cancer Res. 64 (6): 1920–3. doi:10.1158/0008-5472.CAN-03-2827. PMID 15026324.
• Oliveira AM, Perez-Atayde AR, Inwards CY, et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. doi:10.1016/S0002-9440(10)63432-3. PMC 3278819. PMID 15509545.
• Martinu L, Masuda-Robens JM, Robertson SE, et al. (2004). "The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004. PMC 525471. PMID 15509780.
• Oliveira AM, Perez-Atayde AR, Dal Cin P, et al. (2005). "Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes". Oncogene. 24 (21): 3419–26. doi:10.1038/sj.onc.1208506. PMID 15735689.
• Bizimungu C, Vandenbol M (2005). "At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity". Biochem. Biophys. Res. Commun. 335 (3): 883–90. doi:10.1016/j.bbrc.2005.07.159. PMID 16099424.
• Shen C, Ye Y, Robertson SE, et al. (2006). "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6". J. Biol. Chem. 280 (43): 35967–73. doi:10.1074/jbc.M505220200. PMID 16127172.
• Dechamps C, Bach S, Portetelle D, Vandenbol M (2006). "The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton". Biotechnol. Lett. 28 (4): 223–31. doi:10.1007/s10529-005-5523-2. PMID 16555005. S2CID 25625056.