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Protein HSP90B1 PDB 1qy5.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HSP90B1, ECGP, GP96, GRP94, HEL-S-125m, HEL35, TRA1, heat shock protein 90kDa beta family member 1, heat shock protein 90 beta family member 1
External IDs MGI: 98817 HomoloGene: 2476 GeneCards: HSP90B1
RNA expression pattern
PBB GE HSP90B1 216449 x at fs.png

PBB GE HSP90B1 200599 s at fs.png

PBB GE HSP90B1 200598 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 103.93 – 103.95 Mb Chr 10: 86.69 – 86.71 Mb
PubMed search [1] [2]
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Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94, or ERp99, is a chaperone protein that in humans is encoded by the HSP90B1 gene.[3][4]

HSP90B1 is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins.[5][6] It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity.[7] Tumor-derived HSP90B1 (vitespen) has entered clinical trials for cancer immunotherapy.[8][9][10][11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Maki RG, Old LJ, Srivastava PK (August 1990). "Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins". Proc. Natl. Acad. Sci. U.S.A. 87 (15): 5658–62. doi:10.1073/pnas.87.15.5658. PMC 54386Freely accessible. PMID 2377606. 
  4. ^ Chen B, Piel WH, Gui L, Bruford E, Monteiro A (December 2005). "The HSP90 family of genes in the human genome: insights into their divergence and evolution". Genomics. 86 (6): 627–37. doi:10.1016/j.ygeno.2005.08.012. PMID 16269234. 
  5. ^ Randow F, Seed B (2001). "Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability.". Nat. Cell Biol. 3 (10): 891–6. doi:10.1038/ncb1001-891. PMID 11584270. 
  6. ^ Yang Y, et al. (2007). "Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages.". Immunity. 26 (2): 215–226. doi:10.1016/j.immuni.2006.12.005. PMC 2847270Freely accessible. PMID 17275357. ,
  7. ^ Schild H, Rammensee HG (August 2000). "gp96--the immune system's Swiss army knife". Nat. Immunol. 1 (2): 100–1. doi:10.1038/77770. PMID 11248798. 
  8. ^ Wood CG, Mulders P (August 2009). "Vitespen: a preclinical and clinical review". Future Oncol. 5 (6): 763–74. doi:10.2217/fon.09.46. PMID 19663726. 
  9. ^ Tosti G, di Pietro A, Ferrucci PF, Testori A (November 2009). "HSPPC-96 vaccine in metastatic melanoma patients: from the state of the art to a possible future". Expert Rev Vaccines. 8 (11): 1513–26. doi:10.1586/erv.09.108. PMID 19863242. 
  10. ^ "NCT00293423". ClinicalTrials.gov, United States National Institutes of Health. Retrieved 2010-04-10. GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma 
  11. ^ Bloch, O.; Crane, C. A.; Fuks, Y.; Kaur, R.; Aghi, M. K.; Berger, M. S.; Butowski, N. A.; Chang, S. M.; Clarke, J. L.; McDermott, M. W.; Prados, M. D.; Sloan, A. E.; Bruce, J. N.; Parsa, A. T. (12 December 2013). "Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial". Neuro-Oncology. 16: 274–279. doi:10.1093/neuonc/not203. 

Further reading[edit]