PTP4A1

PTP4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RXD, 1XM2
Identifiers
Aliases	PTP4A1, HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, protein tyrosine phosphatase type IVA, member 1, protein tyrosine phosphatase 4A1
External IDs	OMIM: 601585; MGI: 1277096; HomoloGene: 2587; GeneCards: PTP4A1; OMA:PTP4A1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	63,583,436 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; muscle of thigh; ; liver; ; right lobe of liver; ; rectum; ; gastrocnemius muscle; ; ganglionic eminence; ; skeletal muscle tissue; ; ventricular zone; ; smooth muscle tissue;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; protein tyrosine phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; protein binding;
Cellular component	cytoplasm; endosome; membrane; plasma membrane; spindle; early endosome; endoplasmic reticulum; cytoplasmic side of plasma membrane; cytoskeleton; nucleus;
Biological process	positive regulation of cell migration; protein dephosphorylation; multicellular organism development; cell cycle; dephosphorylation; peptidyl-tyrosine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	7803
	19243
	ENSG00000112245
	ENSMUSG00000026064
	Q93096
	Q63739
	NM_003463
	NM_011200
	NP_003454
	NP_035330
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.^[4]^[5]

Interactions

PTP4A1 has been shown to interact with ATF7.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112245 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem. 273 (27): 17286–95. doi:10.1074/jbc.273.27.17286. PMID 9642300.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Cite error: The named reference entrez was invoked but never defined (see the help page).
^ Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17). United States: 13718–26. doi:10.1074/jbc.M011562200. ISSN 0021-9258. PMID 11278933. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)