PTPN13

PTPN13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D5G, 1Q7X, 1WCH, 2M0Z, 2M10, 3LNX, 3LNY, 3PDZ
Identifiers
Aliases	PTPN13, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE, hPTP1E, protein tyrosine phosphatase, non-receptor type 13, protein tyrosine phosphatase non-receptor type 13
External IDs	OMIM: 600267; MGI: 103293; HomoloGene: 7909; GeneCards: PTPN13; OMA:PTPN13 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	86,815,171 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	103,746,169 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; urethra; ; human penis; ; palpebral conjunctiva; ; retinal pigment epithelium; ; skin of arm; ; renal medulla; ; trigeminal ganglion; ; gingival epithelium; ; mucosa of pharynx;
	Top expressed in
	corneal stroma; ; hair follicle; ; mucosa of urinary bladder; ; transitional epithelium of urinary bladder; ; retinal pigment epithelium; ; medullary collecting duct; ; skin of external ear; ; conjunctival fornix; ; skin of back; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; phosphoprotein phosphatase activity; hydrolase activity;
Cellular component	cytoplasm; cell body; neuron projection; cell projection; extracellular exosome; cytoskeleton; nucleus; lamellipodium; plasma membrane; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; regulation of phosphatidylinositol 3-kinase signaling; dephosphorylation; phosphatidylinositol biosynthetic process; negative regulation of protein phosphorylation; cellular response to cytokine stimulus; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	5783
	19249
	ENSG00000163629
	ENSMUSG00000034573
	Q12923
	Q64512
	NM_006264; NM_080683; NM_080684; NM_080685
	NM_011204
	NP_006255; NP_542414; NP_542415; NP_542416
	NP_035334
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.^[5]^[6]

Template:PBB Summary

Interactions

PTPN13 has been shown to interact with PKN2.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163629 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034573 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Maekawa K, Imagawa N, Nagamatsu M, Harada S (Feb 1994). "Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats". FEBS Lett. 337 (2): 200–206. doi:10.1016/0014-5793(94)80273-4. PMID 8287977.
^ "Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)".
^ Gross, C; Heumann R; Erdmann K S (May 2001). "The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif". FEBS Lett. 496 (2–3). Netherlands: 101–104. doi:10.1016/S0014-5793(01)02401-2. ISSN 0014-5793. PMID 11356191. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

Interactions

References

Further reading