3',5'-cyclic-AMP phosphodiesterase
| 3',5'-cyclic-AMP phosphodiesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.4.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with systematic name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- adenosine 3',5'-cyclic phosphate + H2O AMP
This enzyme requires Mg2+ or Mn2+ for activity.
References
- ^ "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145 (1): 40–49. 2006. doi:10.1016/j.molbiopara.2005.09.005. PMID 16225937.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281 (29): 20018–20026. 2006. doi:10.1074/jbc.M600040200. PMID 16644729.
{{cite journal}}: Cite uses deprecated parameter|authors=(help)CS1 maint: unflagged free DOI (link) - ^ "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA. 99 (7): 4714–4719. 2002. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25–25. 2006. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215.
{{cite journal}}: Cite uses deprecated parameter|authors=(help)CS1 maint: unflagged free DOI (link) - ^ "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta. 1472 (3): 431–446. 1999. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757.
{{cite journal}}: Cite uses deprecated parameter|authors=(help) - ^ "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271 (41): 25423–25429. 1996. doi:10.1074/jbc.271.41.25423. PMID 8810311.
{{cite journal}}: Cite uses deprecated parameter|authors=(help)CS1 maint: unflagged free DOI (link)
External links
- 3',5'-cyclic-AMP+phosphodiesterase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)