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Angiopoietin 2
Protein ANGPT2 PDB 1z3s.png
PDB rendering based on 1z3s.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ANGPT2 ; AGPT2; ANG2
External IDs OMIM601922 MGI1202890 HomoloGene22401 GeneCards: ANGPT2 Gene
RNA expression pattern
PBB GE ANGPT2 211148 s at tn.png
PBB GE ANGPT2 205572 at tn.png
More reference expression data
Species Human Mouse
Entrez 285 11601
Ensembl ENSG00000091879 ENSMUSG00000031465
UniProt O15123 O35608
RefSeq (mRNA) NM_001118887 NM_007426
RefSeq (protein) NP_001112359 NP_031452
Location (UCSC) Chr 8:
6.36 – 6.42 Mb
Chr 8:
18.69 – 18.74 Mb
PubMed search [1] [2]

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.[1]

Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1[2]


ANGPT2 has been shown to interact with TEK tyrosine kinase.[3][4][5]

See also[edit]


  1. ^ Cheung AH, Stewart RJ, Marsden PA (Jun 1998). "Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23". Genomics 48 (3): 389–91. doi:10.1006/geno.1997.5207. PMID 9545648. 
  2. ^ "Entrez Gene: ANGPT2 angiopoietin 2". 
  3. ^ Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764. 
  4. ^ Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (Aug 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709. 
  5. ^ Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (Jul 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.