Atamestane

Atamestane

Clinical data
Other names	SH-489; 1-Methylandrosta-1,4-diene-3,17-dione
ATC code	None
Legal status
Legal status	UK: Class C
Identifiers
IUPAC name (8R,9S,10S,13S,14S)-1,10,13-Trimethyl-7,8,9,11,12, 14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-dione
CAS Number	96301-34-7 N
PubChem CID	57050
ChemSpider	51438 Y
UNII	62GA3K28B6
ChEMBL	ChEMBL2105987 N
Chemical and physical data
Formula	C20H26O2
Molar mass	298.419 g/mol g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C\1/C=C(/C)[C@]4(C(=C/1)/CC[C@@H]3[C@@H]4CC[C@@]2(C(=O)CC[C@H]23)C)C
InChI InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1 Y Key:PEPMWUSGRKINHX-TXTPUJOMSA-N Y
NY (what is this?)  (verify)

Atamestane (developmental code name SH-489), also known as 1-methylandrosta-1,4-diene-3,17-dione, is a steroidal aromatase inhibitor that was studied in the treatment of cancer. It blocks the production of estrogen in the body. The drug is selective, competitive, and irreversible in its inhibition of aromatase.

See also

• Boldione (androsta-1,4-diene-3,17-dione)

External links

• Atamestane entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.

Template:Steroid hormone metabolism modulators