Hydroxyflutamide

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Hydroxyflutamide
Hydroxyflutamide.svg
Identifiers
IUPAC name: 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Synonyms Hydroxyniphtholide, hydroxyniftolide; α,α,α-trifluoro-2-methyl-4'-nitro-m-lactotoluidide
CAS Number 52806-53-8
PubChem (CID) 91649
IUPHAR/BPS 2862
ChemSpider 82752
UNII 31D90UKP5Y
KEGG C14204
ChEBI CHEBI:43064
ChEMBL CHEMBL491
Chemical and physical data
Formula C11H11F3N2O4
Molar mass 292.21125 g/mol
3D model (Jmol) Interactive image

Hydroxyflutamide (HF, OHF) (developmental code name SCH-16423), or 2-hydroxyflutamide, is a non-steroidal antiandrogen.[1][2] It is the major active metabolite of flutamide.[2] It is reported to possess an IC50 of 700 nM for the androgen receptor (AR), about 4-fold less than that of bicalutamide.[3]

See also[edit]

References[edit]

  1. ^ Serra, C; Sandor, NL; Jang, H; Lee, D; Toraldo, G; Guarneri, T; Wong, S; Zhang, A; Guo, W; Jasuja, R; Bhasin, S (2013). "The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: Differential effects on high-androgen responder and low-androgen responder muscle groups". Endocrinology. 154 (12): 4594–606. doi:10.1210/en.2013-1004. PMC 3836062Freely accessible. PMID 24105483. 
  2. ^ a b Singh, Shankar; Gauthier, Sylvain; Labrie, Fernand (2000). "Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships". Current Medicinal Chemistry. 7 (2): 211–247. doi:10.2174/0929867003375371. ISSN 0929-8673. 
  3. ^ Furr BJ (1995). "Casodex: preclinical studies and controversies". Annals of the New York Academy of Sciences. 761: 79–96. PMID 7625752.