|Trade names||Lentaron, others|
|AHFS/Drugs.com||International Drug Names|
|Drug class||Aromatase inhibitor; Antiestrogen|
|Chemical and physical data|
|Molar mass||302.408 g/mol|
|3D model (JSmol)|
|(what is this?)|
Formestane, sold under the brand name Lentaron among others, is a steroidal, selective aromatase inhibitor which is used in the treatment of estrogen receptor-positive breast cancer in postmenopausal women. The drug is not active orally, and is instead available only as an intramuscular depot injection. Because of this, it is no longer popular as many orally active aromatase inhibitors have been identified and introduced. Formestane is an analogue of androstenedione.
Formestane is often used to suppress the production of estrogens from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a weak aromatase inhibitor.
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