Auxilin

DNAJC6
Identifiers
Aliases	DNAJC6, DJC6, PARK19, Auxilin, DnaJ heat shock protein family (Hsp40) member C6
External IDs	OMIM: 608375; MGI: 1919935; HomoloGene: 8865; GeneCards: DNAJC6; OMA:DNAJC6 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 65,248,219 bp End 65,415,871 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C6 Start 101,353,828 bp End 101,499,996 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 pars compacta pars reticulata orbitofrontal cortex middle temporal gyrus lateral nuclear group of thalamus pons inferior olivary nucleus Brodmann area 46 Top expressed in medial dorsal nucleus dorsomedial hypothalamic nucleus ventral tegmental area pontine nuclei medial geniculate nucleus paraventricular nucleus of hypothalamus lateral geniculate nucleus piriform cortex primary motor cortex central gray substance of midbrain More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine phosphatase activity SH3 domain binding phosphoprotein phosphatase activity hydrolase activity clathrin binding Cellular component cytosol synapse vesicle postsynaptic density cytoplasm intracellular membrane-bounded organelle presynapse Biological process peptidyl-tyrosine dephosphorylation regulation of clathrin-dependent endocytosis protein dephosphorylation clathrin coat disassembly receptor-mediated endocytosis membrane organization synaptic vesicle uncoating clathrin-dependent endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9829 72685 Ensembl ENSG00000116675 ENSMUSG00000028528 UniProt O75061 Q80TZ3 RefSeq (mRNA) NM_001256864 NM_001256865 NM_014787 NM_001164583 NM_001164584 NM_001164585 NM_198412 NM_001355179 NM_001355180 RefSeq (protein) NP_001243793 NP_001243794 NP_055602 NP_001158055 NP_001158056 NP_001158057 NP_940804 NP_001342108 NP_001342109 Location (UCSC) Chr 1: 65.25 – 65.42 Mb Chr 4: 101.35 – 101.5 Mb PubMed search
Wikidata
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Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

Function

DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).

Structure

The protein tyrosine phosphatase domain and C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.

Further reading

• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (Jul 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. doi:10.1074/jbc.M303738200. PMID 12732633.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Scheele U, Kalthoff C, Ungewickell E (Sep 2001). "Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex". The Journal of Biological Chemistry. 276 (39): 36131–8. doi:10.1074/jbc.M106511200. PMID 11470803.{{cite journal}}: CS1 maint: unflagged free DOI (link)
• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.