CDKN3

CDKN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FPZ, 1FQ1
Identifiers
Aliases	CDKN3, CDI1, CIP2, KAP, KAP1, cyclin-dependent kinase inhibitor 3, cyclin dependent kinase inhibitor 3, CDLN3
External IDs	OMIM: 123832; MGI: 1919641; HomoloGene: 3805; GeneCards: CDKN3; OMA:CDKN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	54,420,218 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,009,126 bp
RNA expression pattern
	Top expressed in
	sperm; ; ganglionic eminence; ; bone marrow; ; trabecular bone; ; rectum; ; stromal cell of endometrium; ; bone marrow cells; ; appendix; ; lymph node; ; oral cavity;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; yolk sac; ; medial ganglionic eminence; ; hand; ; thymus; ; endocardial cushion; ; bone marrow; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatase activity; protein serine/threonine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity;
Cellular component	nucleus; perinuclear region of cytoplasm; cytoplasm; cytosol;
Biological process	cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cell population proliferation; dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1033
	72391
	ENSG00000100526
	ENSMUSG00000037628
	Q16667
	Q810P3
	NM_001130851; NM_005192; NM_001330173
	NM_028222; NM_001360041
	NP_001124323; NP_001317102; NP_005183
	NP_082498; NP_001346970
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

CDKN3 has been shown to interact with Cyclin-dependent kinase 2,^[8]^[9]^[10] Cdk1^[5]^[9] and MS4A3.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.
^ Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.
^ "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".
^ Yeh, Chau-Ting; Lu Su-Chuan; Chao Chung-Hao; Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2). United States: 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ ^a ^b Hannon, G J; Casso D; Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5). UNITED STATES: 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Harper, J W; Adami G R; Wei N; Keyomarsi K; Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4). UNITED STATES: 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

CDKN3 human gene location in the UCSC Genome Browser.
CDKN3 human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037628 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8242750-5] Gyuris J, Golemis E, Chertkov H, Brent R (Dec 1993). "Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2". Cell. 75 (4): 791–803. doi:10.1016/0092-8674(93)90498-F. PMID 8242750.

[pmid7698009-6] Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (May 1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)". Cytogenet Cell Genet. 69 (3–4): 190–2. doi:10.1159/000133960. PMID 7698009.

[entrez-7] "Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)".

[pmid12745075-8] Yeh, Chau-Ting; Lu Su-Chuan; Chao Chung-Hao; Chao Mei-Ling (May 2003). "Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant". Biochem. Biophys. Res. Commun. 305 (2). United States: 311–4. doi:10.1016/S0006-291X(03)00757-5. ISSN 0006-291X. PMID 12745075. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

[pmid8127873-9] Hannon, G J; Casso D; Beach D (Mar 1994). "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 91 (5). UNITED STATES: 1731–5. Bibcode:1994PNAS...91.1731H. doi:10.1073/pnas.91.5.1731. ISSN 0027-8424. PMC 43237. PMID 8127873. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

[pmid8242751-10] Harper, J W; Adami G R; Wei N; Keyomarsi K; Elledge S J (Nov 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4). UNITED STATES: 805–16. doi:10.1016/0092-8674(93)90499-G. ISSN 0092-8674. PMID 8242751. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid11781350-11] Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1). United States: 51–8. doi:10.1172/JCI14025. ISSN 0021-9738. PMC 150822. PMID 11781350. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

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Interactions

References

Further reading

External links